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Senescence\u2010related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence\u2010associated secretory phenotype (SASP). Emerging evidence suggests that the presence of these proinflammatory and matrix\u2010degrading molecules has deleterious effects in a variety of tissues. In the current study, we demonstrated in a transgenic mouse model that early removal of senescent cells induced upon elevated intraocular pressure (IOP) protects unaffected RGCs from senescence and apoptosis. Visual evoked potential (VEP) analysis demonstrated that remaining RGCs are functional and that the treatment protected visual functions. Finally, removal of endogenous senescent retinal cells after IOP elevation by a treatment with senolytic drug dasatinib prevented loss of retinal functions and cellular structure. Senolytic drugs may have the potential to mitigate the deleterious impact of elevated IOP on RGC survival in glaucoma and other optic neuropathies.<\/jats:p>","DOI":"10.1111\/acel.13089","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T02:39:51Z","timestamp":1577068791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension"],"prefix":"10.1111","volume":"19","author":[{"given":"Lorena Raquel","family":"Rocha","sequence":"first","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viet Anh","family":"Nguyen Huu","sequence":"additional","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Palomino La Torre","sequence":"additional","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlan","family":"Xu","sequence":"additional","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jabari","sequence":"additional","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5758-4225","authenticated-orcid":false,"given":"Dorota","family":"Skowronska\u2010Krawczyk","sequence":"additional","affiliation":[{"name":"Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA"},{"name":"Richard C. Atkinson Lab for Regenerative Ophthalmology University of California, San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16932"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10600"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75421-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.052738"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2017.1413659"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6659"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.02.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.11.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0795-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4324"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0042-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05092"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.169"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1038"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12234"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303491110"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.05.008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2005.09.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","unstructured":"Rocha L. 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