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Reagents that target cells in a specific cell cycle phase (e.g., antimitotics or DNA synthesis inhibitors\/replication stress inducers) have demonstrated success as broad\u2010spectrum anticancer drugs. Cyclin\u2010dependent kinases (CDKs) are drivers of cell cycle transitions. A CDK inhibitor, flavopiridol\/alvocidib, is an FDA\u2010approved drug for acute myeloid leukemia. Alzheimer's disease (AD) is another serious issue in contemporary medicine. The cause of AD remains elusive, although a critical role of latent amyloid\u2010beta accumulation has emerged. Existing AD drug research and development targets include amyloid, amyloid metabolism\/catabolism, tau, inflammation, cholesterol, the cholinergic system, and other neurotransmitters. However, none have been validated as therapeutically effective targets. Recent reports from AD\u2010omics and preclinical animal models provided data supporting the long\u2010standing notion that cell cycle progression and\/or mitosis may be a valid target for AD prevention and\/or therapy. This review will summarize the recent developments in AD research: (a) Mitotic re\u2010entry, leading to the \u201camyloid\u2010beta accumulation cycle,\u201d may be a prerequisite for amyloid\u2010beta accumulation and AD pathology development; (b) AD\u2010associated pathogens can cause cell cycle errors; (c) thirteen among 37 human AD genetic risk genes may be functionally involved in the cell cycle and\/or mitosis; and (d) preclinical AD mouse models treated with CDK inhibitor showed improvements in cognitive\/behavioral symptoms. If the \u201camyloid\u2010beta accumulation cycle is an AD drug target\u201d concept is proven, repurposing of cancer drugs may emerge as a new, fast\u2010track approach for AD management in the clinic setting.<\/jats:p>","DOI":"10.1111\/acel.13109","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T15:14:15Z","timestamp":1579965255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["\u201cAmyloid\u2010beta accumulation cycle\u201d as a prevention and\/or therapy target for Alzheimer's disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Chinthalapally V.","family":"Rao","sequence":"first","affiliation":[{"name":"Center for Cancer Prevention and Drug Development Department of Medicine Hematology\/Oncology Section University of Oklahoma Health Sciences Center (OUHSC) Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Asch","sequence":"additional","affiliation":[{"name":"Stephenson Cancer Center Department of Medicine Hematology\/Oncology Section University of Oklahoma Health Sciences Center (OUHSC) Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J. 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