{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:03:44Z","timestamp":1792757024719,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["11183"],"award-info":[{"award-number":["11183"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent reports highlight regulatory functions of long noncoding RNAs (lncRNAs) in neurodegeneration and aging, but biomedical implications remain limited. Here, we report an rRNA\u2010depletion\u2010based long RNA\u2010Sequencing Resource of 65 substantia nigra, amygdala, and medial temporal gyrus samples from Parkinson's disease (PD) and matched control brains. Using a lncRNA\u2010focused analysis approach to identify functionally important transcripts, we discovered and prioritized many lncRNAs dysregulated in PD. Those included pronounced elevation of the P53\u2010induced noncoding transcript LINC\u2010PINT in the substantia nigra of PD patients, as well as in additional models of oxidative stress and PD. Intriguingly, we found that LINC\u2010PINT is a primarily neuronal transcript which showed conspicuous increases in maturing primary culture neurons. LINC\u2010PINT also accumulated in several brain regions of Alzheimer's and Huntington's disease patients and decreased with healthy brain aging, suggesting a general role in aging and neurodegeneration for this lncRNA. RNAi\u2010mediated depletion of LINC\u2010PINT exacerbated the death of cultured N2A and SH\u2010SY5Y cells exposed to oxidative stress, highlighting a previously undiscovered neuroprotective role for this tumor\u2010inducible lncRNA in the brains of patients with neurodegenerative disorders.<\/jats:p>","DOI":"10.1111\/acel.13115","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T07:37:41Z","timestamp":1582270661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["A lncRNA survey finds increases in neuroprotective LINC\u2010PINT in Parkinson\u2019s disease <i>substantia nigra<\/i>"],"prefix":"10.1111","volume":"19","author":[{"given":"Alon","family":"Simchovitz","sequence":"first","affiliation":[{"name":"The Department of Biological Chemistry and The Edmond and Lily Safra Center for Brain Sciences The Hebrew University of Jerusalem Jerusalem 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R.","family":"Bennett","sequence":"additional","affiliation":[{"name":"The Department of Biological Chemistry and The Edmond and Lily Safra Center for Brain Sciences The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"The Department of Biological Chemistry and The Edmond and Lily Safra Center for Brain Sciences The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kadener","sequence":"additional","affiliation":[{"name":"Biology Department Brandeis University Waltham MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-526X","authenticated-orcid":false,"given":"Hermona","family":"Soreq","sequence":"additional","affiliation":[{"name":"The Department of Biological Chemistry and The Edmond and Lily Safra Center 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