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We found that skeletal muscle recovery was impaired in old compared with young mice after influenza A virus\u2010induced pneumonia. In young mice, recovery of muscle loss was associated with expansion of tissue\u2010resident skeletal muscle macrophages and downregulation of MHC II expression, followed by a proliferation of muscle satellite cells. These findings were absent in old mice and in mice deficient in\n                    <jats:italic>Cx3cr1<\/jats:italic>\n                    . Transcriptomic profiling of tissue\u2010resident skeletal muscle macrophages from old compared with young mice showed downregulation of pathways associated with phagocytosis and proteostasis, and persistent upregulation of inflammatory pathways. Consistently, skeletal muscle macrophages from old mice failed to downregulate MHCII expression during recovery from influenza A virus\u2010induced pneumonia and showed impaired phagocytic function\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Like old animals, mice deficient in the phagocytic receptor\n                    <jats:italic>Mertk<\/jats:italic>\n                    showed no macrophage expansion, MHCII downregulation, or satellite cell proliferation and failed to recover skeletal muscle function after influenza A pneumonia. Our data suggest that a loss of phagocytic function in a CX3CR1\n                    <jats:sup>+<\/jats:sup>\n                    tissue\u2010resident skeletal muscle macrophage population in old mice precludes satellite cell proliferation and recovery of skeletal muscle function after influenza A pneumonia.\n                  <\/jats:p>","DOI":"10.1111\/acel.13180","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T09:10:41Z","timestamp":1595927441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Impaired phagocytic function in CX3CR1\n                    <sup>+<\/sup>\n                    tissue\u2010resident skeletal muscle macrophages prevents muscle recovery after influenza A virus\u2010induced pneumonia in old mice"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-7997","authenticated-orcid":false,"given":"Constance 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