{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:04:11Z","timestamp":1791925451471,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis (OA) is the most prevalent disabling disease, affecting quality of life and contributing to morbidity, particularly during aging. Current treatments for OA are limited to palliation: pain management and surgery for end\u2010stage disease. Innovative approaches and animal models are needed to develop curative treatments for OA. Here, we investigated the naked mole\u2010rat (NMR) as a potential model of OA resistance. NMR is a small rodent with the maximum lifespan of over 30\u00a0years, resistant to a wide range of age\u2010related diseases. NMR tissues accumulate large quantities of unique, very high molecular weight, hyaluronan (HA). HA is a major component of cartilage and synovial fluid. Importantly, both HA molecular weight and cartilage stiffness decline with age and progression of OA. As increased polymer length is known to result in stiffer material, we hypothesized that NMR high molecular weight HA contributes to stiffer cartilage. Our analysis of biomechanical properties of NMR cartilage revealed that it is significantly stiffer than mouse cartilage. Furthermore, NMR chondrocytes were highly resistant to traumatic damage. In vivo experiments using an injury\u2010induced model of OA revealed that NMRs were highly resistant to OA. While similarly treated mice developed severe cartilage degeneration, NMRs did not show any signs of OA. Our study shows that NMRs are remarkably resistant to OA, and this resistance is likely conferred by high molecular weight HA. This work suggests that NMR is a useful model to study OA resistance and NMR high molecular weight HA may hold therapeutic potential for OA treatment.<\/jats:p>","DOI":"10.1111\/acel.13255","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T14:36:29Z","timestamp":1603895789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Naked mole\u2010rats are extremely resistant to post\u2010traumatic osteoarthritis"],"prefix":"10.1111","volume":"19","author":[{"given":"Taketo","family":"Taguchi","sequence":"first","affiliation":[{"name":"Departments of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kotelsky","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Takasugi","sequence":"additional","affiliation":[{"name":"Departments of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester School of Medicine Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghe","family":"Ke","sequence":"additional","affiliation":[{"name":"Departments of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Betancourt","sequence":"additional","affiliation":[{"name":"Departments of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zuscik","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research University of Rochester School of Medicine Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Seluanov","sequence":"additional","affiliation":[{"name":"Departments of Biology and Medicine University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-0333","authenticated-orcid":false,"given":"Vera","family":"Gorbunova","sequence":"additional","affiliation":[{"name":"Departments of Biology and Medicine University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.3138475"},{"key":"e_1_2_9_4_1","first-page":"63","volume-title":"Disorders of the knee","author":"Balazs E. 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