{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:04:13Z","timestamp":1790975053927,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG032643, GM109005"],"award-info":[{"award-number":["AG032643, GM109005"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Age\u2010associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial properties in both sarcopenia and CVD. Sulforaphane (SFN), a natural compound Nrf2\u2010related activator of cytoprotective genes, provides protection in several disease states including CVD and is in various stages of clinical trials, from cancer prevention to reducing insulin resistance. This study aimed to determine whether SFN may prevent age\u2010related loss of function in the heart and skeletal muscle. Cohorts of 2\u2010month\u2010old and 21\u2010 to 22\u2010month\u2010old mice were administered regular rodent diet or diet supplemented with SFN for 12\u00a0weeks. At the completion of the study, skeletal muscle and heart function, mitochondrial function, and Nrf2 activity were measured. Our studies revealed a significant drop in Nrf2 activity and mitochondrial functions, together with a loss of skeletal muscle and cardiac function in the old control mice compared to the younger age group. In the old mice, SFN restored Nrf2 activity, mitochondrial function, cardiac function, exercise capacity, glucose tolerance, and activation\/differentiation of skeletal muscle satellite cells. Our results suggest that the age\u2010associated decline in Nrf2 signaling activity and the associated mitochondrial dysfunction might be implicated in the development of age\u2010related disease processes. Therefore, the restoration of Nrf2 activity and endogenous cytoprotective mechanisms by SFN may be a safe and effective strategy to protect against muscle and heart dysfunction due to aging.<\/jats:p>","DOI":"10.1111\/acel.13261","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T04:12:15Z","timestamp":1602907935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Sulforaphane prevents age\u2010associated cardiac and muscular dysfunction through Nrf2 signaling"],"prefix":"10.1111","volume":"19","author":[{"given":"Chhanda","family":"Bose","sequence":"first","affiliation":[{"name":"Division of Hematology &amp; Oncology Department of Internal Medicine Texas Tech University Medical Sciences Center  Lubbock TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Alves","sequence":"additional","affiliation":[{"name":"Arkansas Children's Research Institute  Little Rock AR USA"},{"name":"Center for Neuroscience and Cell Biology University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip T.","family":"Palade","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Arkansas Children's Research Institute  Little Rock AR USA"},{"name":"Center for Neuroscience and Cell Biology University of Coimbra  Coimbra Portugal"},{"name":"Department of Geriatrics University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"B\u00f8rsheim","sequence":"additional","affiliation":[{"name":"Arkansas Children's Research Institute  Little Rock AR USA"},{"name":"Department of Geriatrics University of Arkansas for Medical Sciences  Little Rock AR USA"},{"name":"Arkansas Children\u2019s Nutrition Center Department of Pediatrics University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u2010Ran","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Cheema","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Biochemistry, Molecular and Cellular Biology Georgetown University Medical Center  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Boerma","sequence":"additional","affiliation":[{"name":"Division of Radiation Health Department of Pharmaceutical Sciences University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; 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