{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:21:00Z","timestamp":1791937260639,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002287","name":"Progeria Research Foundation","doi-asserted-by":"publisher","award":["2019\u201076"],"award-info":[{"award-number":["2019\u201076"]}],"id":[{"id":"10.13039\/100002287","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hutchinson\u2013Gilford progeria syndrome (HGPS) causes premature aging in children, with adipose tissue, skin and bone deterioration, and cardiovascular impairment. In HGPS cells and mouse models, high levels of interleukin\u20106, an inflammatory cytokine linked to aging processes, have been detected. Here, we show that inhibition of interleukin\u20106 activity by tocilizumab, a neutralizing antibody raised against interleukin\u20106 receptors, counteracts progeroid features in both HGPS fibroblasts and\n                    <jats:italic>\n                      Lmna\n                      <jats:sup>G609G<\/jats:sup>\n                    <\/jats:italic>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:italic>\n                      <jats:sup>G609G<\/jats:sup>\n                    <\/jats:italic>\n                    progeroid mice. Tocilizumab treatment limits the accumulation of progerin, the toxic protein produced in HGPS cells, rescues nuclear envelope and chromatin abnormalities, and attenuates the hyperactivated DNA damage response. In vivo administration of tocilizumab reduces aortic lesions and adipose tissue dystrophy, delays the onset of lipodystrophy and kyphosis, avoids motor impairment, and preserves a good quality of life in progeroid mice. This work identifies tocilizumab as a valuable tool in HGPS therapy and, speculatively, in the treatment of a variety of aging\u2010related disorders.\n                  <\/jats:p>","DOI":"10.1111\/acel.13285","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T01:31:06Z","timestamp":1609723866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Interleukin\u20106 neutralization ameliorates symptoms in prematurely aged mice"],"prefix":"10.1111","volume":"20","author":[{"given":"Stefano","family":"Squarzoni","sequence":"first","affiliation":[{"name":"CNR Institute of Molecular Genetics \u201cLuigi Luca Cavalli\u2010Sforza\u201d Unit of Bologna Bologna Italy"},{"name":"IRCCS Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Schena","sequence":"additional","affiliation":[{"name":"CNR Institute of Molecular 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