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Efforts have been made to improve immunity in aged populations; however, safe and effective protocols to accomplish this goal have not been universally established. Aging\u2010associated chronic inflammation is postulated to compromise immunity in aged mice and humans. Interleukin\u201037 (IL\u201037) is a potent anti\u2010inflammatory cytokine, and we present data demonstrating that IL\u201037 gene expression levels in human monocytes significantly decline with age. Furthermore, we demonstrate that transgenic expression of interleukin\u201037 (IL\u201037) in aged mice reduces or prevents aging\u2010associated chronic inflammation, splenomegaly, and accumulation of myeloid cells (macrophages and dendritic cells) in the bone marrow and spleen. Additionally, we show that IL\u201037 expression decreases the surface expression of programmed cell death protein 1 (PD\u20101) and augments cytokine production from aged T\u2010cells. Improved T\u2010cell function coincided with a youthful restoration of\n                    <jats:italic>Pdcd1<\/jats:italic>\n                    ,\n                    <jats:italic>Lat<\/jats:italic>\n                    , and\n                    <jats:italic>Stat4<\/jats:italic>\n                    gene expression levels in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells and\n                    <jats:italic>Lat<\/jats:italic>\n                    in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells when aged mice were treated with recombinant IL\u201037 (rIL\u201037) but not control immunoglobin (Control Ig). Importantly, IL\u201037\u2010mediated rejuvenation of aged endogenous T\u2010cells was also observed in aged chimeric antigen receptor (CAR) T\u2010cells, where improved function significantly extended the survival of mice transplanted with leukemia cells. Collectively, these data demonstrate the potency of IL\u201037 in boosting the function of aged T\u2010cells and highlight its therapeutic potential to overcome aging\u2010associated immunosenescence.\n                  <\/jats:p>","DOI":"10.1111\/acel.13309","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T17:41:18Z","timestamp":1611337278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Interleukin\u201037 improves T\u2010cell\u2010mediated immunity and chimeric antigen receptor T\u2010cell therapy in aged backgrounds"],"prefix":"10.1111","volume":"20","author":[{"given":"Jamie A. 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