{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:02:05Z","timestamp":1790665325132,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Senescence phenotypes and mitochondrial dysfunction are implicated in aging and in premature aging diseases, including ataxia telangiectasia (A\u2010T). Loss of mitochondrial function can drive age\u2010related decline in the brain, but little is known about whether improving mitochondrial homeostasis alleviates senescence phenotypes. We demonstrate here that mitochondrial dysfunction and cellular senescence with a senescence\u2010associated secretory phenotype (SASP) occur in A\u2010T patient fibroblasts, and in ATM\u2010deficient cells and mice. Senescence is mediated by stimulator of interferon genes (STING) and involves ectopic cytoplasmic DNA. We further show that boosting intracellular NAD\n                    <jats:sup>+<\/jats:sup>\n                    levels with nicotinamide riboside (NR) prevents senescence and SASP by promoting mitophagy in a PINK1\u2010dependent manner. NR treatment also prevents neurodegeneration, suppresses senescence and neuroinflammation, and improves motor function in\n                    <jats:italic>\n                      Atm\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Our findings suggest a central role for mitochondrial dysfunction\u2010induced senescence in A\u2010T pathogenesis, and that enhancing mitophagy as a potential therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1111\/acel.13329","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T09:09:03Z","timestamp":1616058543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["NAD\n                    <sup>+<\/sup>\n                    supplementation prevents STING\u2010induced senescence in ataxia telangiectasia by improving mitophagy"],"prefix":"10.1111","volume":"20","author":[{"given":"Beimeng","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Gerontology National Institute on Aging NIH Baltimore MD 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