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TMJ degeneration occurs primarily in the population over 65, significantly increasing the risk of joint discomfort, restricted joint mobility, and reduced quality of life. Unfortunately, there is currently no effective mechanism\u2010based treatment available in the clinic to alleviate TMJ degeneration with aging. We now demonstrate that intermittent administration of senolytics, drugs which can selectively clear senescent cells, preserved mandibular condylar cartilage thickness, improved subchondral bone volume and turnover, and reduced Osteoarthritis Research Society International (OARSI) histopathological score in both 23\u2010 to 24\u2010month\u2010old male and female mice. Senolytics had little effect on 4\u00a0months old young mice, indicating age\u2010specific benefits. Our study provides proof\u2010of\u2010concept evidence that age\u2010related TMJ degeneration can be alleviated by pharmaceutical intervention targeting cellular senescence. Since the senolytics used in this study have been proven relatively safe in recent human studies, our findings may help justify future clinical trials addressing TMJ degeneration in old age.<\/jats:p>","DOI":"10.1111\/acel.13394","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T09:33:29Z","timestamp":1623231209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Senolytics alleviate the degenerative disorders of temporomandibular joint in old age"],"prefix":"10.1111","volume":"20","author":[{"given":"Yueying","family":"Zhou","sequence":"first","affiliation":[{"name":"Xiangya Stomatological Hospital and School of Stomatology Central South University Changsha Hunan China"},{"name":"UConn Center on Aging UConn Health Farmington CT USA"},{"name":"Center for Regenerative Medicine and Skeletal Development UConn Health Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman M. 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