{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:56:12Z","timestamp":1792086972711,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10302206\u2010006\u2010007"],"award-info":[{"award-number":["2018ZX10302206\u2010006\u2010007"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372138"],"award-info":[{"award-number":["81372138"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771518"],"award-info":[{"award-number":["81771518"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91849108"],"award-info":[{"award-number":["91849108"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972270"],"award-info":[{"award-number":["81972270"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver ageing not only damages liver function but also harms systemic metabolism. To better understand the mechanisms underlying liver ageing, we transplanted the livers of young rats to young and old rats and performed untargeted metabolomics to detect changes in the metabolites in the liver tissues and sera. A total of 153 metabolites in the livers and 83 metabolites in the sera were different between the old and young rats that did not undergo liver transplantation; among these metabolites, 7 different metabolites were observed in both the livers and sera. Five weeks after liver transplantation, the levels of 25 metabolites in the young donor livers were similar to those in the old rats, and this result probably occurred due to the effect of the whole\u2010body environment of the older recipients on the young livers. The 25 altered metabolites included organic acids and derivatives, lipids and lipid\u2010like molecules, etc. In the sera, the differences in 78 metabolites, which were significant between the young and old rats, were insignificant in the old recipient rats and made the metabolic profile of the old recipients more similar to that of the young recipients. Finally, combining the above metabolomic data with the transcriptomic data from the GEO, we found that the altered metabolites and genes in the liver were enriched in 9 metabolic pathways, including glycerophospholipid, arachidonic acid, histidine and linoleate. Thus, this study revealed important age\u2010related metabolites and potential pathways as well as the interaction between the liver and the whole\u2010body environment.<\/jats:p>","DOI":"10.1111\/acel.13425","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T19:32:28Z","timestamp":1624390348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Age\u2010related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats"],"prefix":"10.1111","volume":"20","author":[{"given":"Qunhua","family":"Han","sequence":"first","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic\u2010chemical Injury Diseases The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Department of Pathology &amp; Pathophysiology, and Cancer Institute of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"NHFPC Key Laboratory of Combined Multi\u2010Organ Transplantation The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic\u2010chemical Injury Diseases The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic\u2010chemical Injury Diseases The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoxian","family":"Meng","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Department of Pathology and Pathophysiology, and Key Laboratory of Disease Proteomics of Zhejiang Province Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Pathophysiology, and Cancer Institute of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Department of Pathology and Pathophysiology, and Key Laboratory of Disease Proteomics of Zhejiang Province Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang University Cancer Center Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic\u2010chemical Injury Diseases The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1537-2638","authenticated-orcid":false,"given":"Lijun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic\u2010chemical Injury Diseases The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.41"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.08.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03260"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2496-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1445-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.10.020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.12.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq048"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01394"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20937"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020376"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2622"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121972"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000176"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2011.1286"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.06.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.031"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i24.3009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v37.i2-6.20"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10050186"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.12.020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154320"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.11.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2499-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.06.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12128"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr201263q"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368115"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1579-y"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2061-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090222"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24394"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4230"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030201"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.13425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:15:36Z","timestamp":1693304136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.13425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/acel.13425"],"URL":"https:\/\/doi.org\/10.1111\/acel.13425","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"2021-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13425"}}