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Growth hormone (GH) has been suggested to play significant roles in maintaining articular chondrocyte function and ultimately articular cartilage (AC) homeostasis. In humans, the age\u2010associated decline in GH levels was hypothesized to play a role in the etiology of OA. We studied the impact of adult\u2010onset isolated GH deficiency (AOiGHD) on the life span and skeletal integrity including the AC, in 23\u2010 to 30\u2010month\u2010old male and female mice on C57\/BL6 genetic background. Reductions in GH during adulthood were associated with extended life span and reductions in body temperature in female mice only. However, end\u2010of\u2010life pathology revealed high levels of lymphomas in both sexes, independent of GH status. Skeletal characterization revealed increases in OA severity in AOiGHD mice, evidenced by AC degradation in both femur and tibia, and significantly increased osteophyte formation in AOiGHD females. AOiGHD males showed significant increases in the thickness of the synovial lining cell layer that was associated with increased markers of inflammation (IL\u20106, iNOS). Furthermore, male AOiGHD showed significant increases in matrix metalloproteinase\u201013 (MMP\u201013), p16, and \u03b2\u2010galactosidase immunoreactivity in the AC as compared to controls, indicating increased cell senescence. In conclusion, while the life span of AOiGHD females increased, their health span was compromised by high\u2010grade lymphomas and the development of severe OA. In contrast, AOiGHD males, which did not show extended life span, showed an overall low grade of lymphomas but exhibited significantly decreased health span, evidenced by increased OA severity.<\/jats:p>","DOI":"10.1111\/acel.13427","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T11:48:29Z","timestamp":1625831309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sexual dimorphic impact of adult\u2010onset somatopause on life span and age\u2010induced osteoarthritis"],"prefix":"10.1111","volume":"20","author":[{"given":"Sher Bahadur","family":"Poudel","sequence":"first","affiliation":[{"name":"Department of Molecular Pathobiology David B. Kriser Dental Center New York University College of Dentistry  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology David B. Kriser Dental Center New York University College of Dentistry  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gozde","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology David B. Kriser Dental Center New York University College of Dentistry  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Cordoba\u2010Chacon","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, and Metabolism Department of Medicine University of Illinois at Chicago  Chicago IL USA"},{"name":"Research and Development Division Jesse Brown VA Medical Center  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel D.","family":"Gahete","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, and Metabolism Department of Medicine University of Illinois at Chicago  Chicago IL USA"},{"name":"Research and Development Division Jesse Brown VA Medical Center  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikeno","family":"Yuji","sequence":"additional","affiliation":[{"name":"Barshop Institute for Longevity and Aging Studies UTHSCSA  San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery NYU Grossman School of Medicine  New York NY USA"},{"name":"Department of Biomedical Engineering NYU Tandon School of Engineering  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda D.","family":"Kineman","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, and Metabolism Department of Medicine University of Illinois at Chicago  Chicago IL USA"},{"name":"Research and Development Division Jesse Brown VA Medical Center  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-1330","authenticated-orcid":false,"given":"Shoshana","family":"Yakar","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology David B. 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