{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:26:57Z","timestamp":1790497617055,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Immunosenescence is a hallmark of aging and manifests as increased susceptibility to infection, autoimmunity, and cancer in the elderly. One component of immunosenescence is thymic involution, age\u2010associated shrinkage of the thymus, observed in all vertebrates studied to date. The naked mole rat (\n                    <jats:italic>Heterocephalus glaber<\/jats:italic>\n                    ) has become an attractive animal model in aging research due to its extreme longevity and resistance to disease. Here, we show that naked mole rats display no thymic involution up to 11\u00a0years of age. Furthermore, we found large ectopic cervical thymi in addition to the canonical thoracic thymus, both being identical in their cell composition. The developmental landscape in naked mole rat thymi revealed overt differences from the murine T\u2010cell compartment, most notably a decrease of CD4\n                    <jats:sup>+<\/jats:sup>\n                    \/CD8\n                    <jats:sup>+<\/jats:sup>\n                    double\u2010positive cells and lower abundance of cytotoxic effector T cells. Our observations suggest that naked mole rats display a delayed immunosenescence. Therapeutic interventions aimed at reversing thymic aging remain limited, underscoring the importance of understanding the cellular and molecular mechanisms behind a sustained immune function in the naked mole rat.\n                  <\/jats:p>","DOI":"10.1111\/acel.13477","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T15:58:54Z","timestamp":1633103934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ectopic cervical thymi and no thymic involution until midlife in naked mole rats"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0537-4242","authenticated-orcid":false,"given":"Stephan","family":"Emmrich","sequence":"first","affiliation":[{"name":"Department of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Tolibzoda Zakusilo","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Trapp","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genetics Albert Einstein College of Medicine New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Irving","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Drage","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengdong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genetics Albert Einstein College of Medicine New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-7016","authenticated-orcid":false,"given":"Vadim N.","family":"Gladyshev","sequence":"additional","affiliation":[{"name":"Division of Genetics Department of Medicine Brigham and Women\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-538X","authenticated-orcid":false,"given":"Andrei","family":"Seluanov","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-0333","authenticated-orcid":false,"given":"Vera","family":"Gorbunova","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109992180"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1435"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-007-0237-5"},{"issue":"21","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"pe7","DOI":"10.1126\/sageke.2002.21.pe7","article-title":"The naked mole rat\u2013a new record for the oldest living rodent","volume":"2002","author":"Buffenstein R.","year":"2002","journal-title":"Science of Aging Knowledge Environment: SAGE KE"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-020-00012-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21225"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200525983"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-821413"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812471543"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985816630796"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2012.04.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.6484"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.52.1.41"},{"key":"e_1_2_9_16_1","first-page":"859454","article-title":"The hematopoietic landscape at single\u2010cell resolution reveals unexpected stem cell features in naked mole\u2010rats","author":"Emmrich S.","year":"2019","journal-title":"bioRxiv"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0849-4_10"},{"key":"e_1_2_9_18_1","volume-title":"Longevity, senescence, and the genome","author":"Finch C. E.","year":"1990"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3728"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.059998"},{"key":"e_1_2_9_21_1","volume-title":"Wintrobe's clinical hematology","author":"Greer J. P.","year":"2019"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000528"},{"key":"e_1_2_9_23_1","first-page":"259374","article-title":"T cell immunity does not age in a long\u2010lived rodent species","author":"Izraelson M.","year":"2018","journal-title":"bioRxiv"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1769"},{"issue":"1","key":"e_1_2_9_25_1","first-page":"89","article-title":"Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups","volume":"53","author":"Ke Z.","year":"2014","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-018-0014-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4295"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.04.003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180405"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.245"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.007"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00198-8"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00316"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03582.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00098"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lipd.12286"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00187"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31157"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00210-0"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.06.002"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00122-5"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302259"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.05.001"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2015"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4380"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.3.666.666"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12234"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418203112"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01399"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10409"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.11.B492"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192698"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107949"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.13477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:10:31Z","timestamp":1693347031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.13477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/acel.13477"],"URL":"https:\/\/doi.org\/10.1111\/acel.13477","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740910516.793589368","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.01.454657","asserted-by":"object"}]},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13477"}}