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Growing evidence has suggested the involvement of cerebrovascular dysfunction in the initiation and progression of cognitive impairment in AD and CAA patients. Therefore, in this study, we assessed the brain vasculome in a mouse model in order to identify cerebrovascular pathways that may be involved in AD and CAA vascular pathogenesis in the context of aging. Brain endothelial cells were isolated from young and old wild\u2010type mice, and young and old transgenic mice expressing Swedish mutation in amyloid precursor protein and exon 9 deletion in presenilin 1 (APPswe\/PSEN1dE9). Microarray profiling of these endothelial transcriptomes demonstrated that accumulation of vascular A\u03b2 in the aging APPswe\/PSEN1dE9 mouse is associated with impaired endothelial expression of neurotransmitter receptors and calcium signaling transductors, while the genes involved in cell cycle and inflammation were upregulated. These results suggest that the vascular pathology of AD and CAA may involve the disruption of neurovascular coupling, reactivation of cell cycle in quiescent endothelial cells, and enhanced inflammation. Further dissection of these endothelial mechanisms may offer opportunities to pursue therapies to ameliorate vascular dysfunction in the aging brain of AD and CAA patients.<\/jats:p>","DOI":"10.1111\/acel.13503","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T06:44:27Z","timestamp":1658213067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of cerebral amyloid angiopathy on the brain vasculome"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-4669","authenticated-orcid":false,"given":"Wenjun","family":"Deng","sequence":"first","affiliation":[{"name":"Neuroprotection Research Laboratories Department of Radiology and Neurology Massachusetts General Hospital Harvard Medical School  Charlestown Massachusetts USA"},{"name":"Department of Neurology Clinical Proteomics Research Center Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Neuroprotection Research Laboratories Department of Radiology and Neurology Massachusetts General Hospital Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne J.","family":"van Veluw","sequence":"additional","affiliation":[{"name":"Department of Neurology J. 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