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Current neuroregenerative research is largely directed toward identifying the molecular and cellular players that underlie central nervous system repair, yet it repeatedly ignores the aging context in which many of these diseases appear. Using an optic nerve crush model in a novel biogerontology model, <jats:italic>that is<\/jats:italic>, the short\u2010living African turquoise killifish, the impact of aging on injury\u2010induced optic nerve repair was investigated. This work reveals an age\u2010related decline in axonal regeneration in female killifish, with different phases of the repair process being affected depending on the age. Interestingly, as in mammals, both a reduced intrinsic growth potential and a non\u2010supportive cellular environment seem to lie at the basis of this impairment. Overall, we introduce the killifish visual system and its age\u2010dependent regenerative ability as a model to identify new targets for neurorepair in non\u2010regenerating individuals, thereby also considering the effects of aging on neurorepair.<\/jats:p>","DOI":"10.1111\/acel.13537","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T04:45:07Z","timestamp":1639975507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short\u2010living killifish"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1664-4292","authenticated-orcid":false,"given":"Sophie","family":"Vanhunsel","sequence":"first","affiliation":[{"name":"Neural Circuit Development and Regeneration Research Group Animal Physiology and Neurobiology Section Department of 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