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In this study, we performed the first genome\u2010wide methylation analysis on blood DNA of 15 patients with progeroid laminopathies using Infinium Methylation EPIC arrays including 8 patients with classical HGPS. We could observe DNA methylation alterations at 61 CpG sites as well as 32\u00a0significant regions following a 5\u00a0Kb tiling analysis. Differentially methylated probes were enriched for phosphatidylinositol biosynthetic process, phospholipid biosynthetic process, sarcoplasm, sarcoplasmic reticulum, phosphatase regulator activity, glycerolipid biosynthetic process, glycerophospholipid biosynthetic process, and phosphatidylinositol metabolic process. Differential methylation analysis at the level of promoters and CpG islands revealed no significant methylation changes in blood DNA of progeroid laminopathy patients. Nevertheless, we could observe significant methylation differences in classic HGPS when specifically looking at probes overlapping solo\u2010WCGW partially methylated domains. Comparing aberrantly methylated sites in progeroid laminopathies, classic Werner syndrome, and Down syndrome revealed a common significantly hypermethylated region in close vicinity to the transcription start site of a long non\u2010coding RNA located anti\u2010sense to the Catenin Beta Interacting Protein 1\u00a0gene (<jats:italic>CTNNBIP1<\/jats:italic>). By characterizing epigenetically altered sites, we identify possible pathways\/mechanisms that might have a role in the accelerated aging of progeroid laminopathies.<\/jats:p>","DOI":"10.1111\/acel.13555","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T19:10:26Z","timestamp":1642619426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["DNA methylation signatures in Blood DNA of Hutchinson\u2013Gilford Progeria syndrome"],"prefix":"10.1111","volume":"21","author":[{"given":"Yosra","family":"Bejaoui","sequence":"first","affiliation":[{"name":"College of Health and Life Sciences Qatar Foundation Hamad Bin Khalifa University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleem","family":"Razzaq","sequence":"additional","affiliation":[{"name":"College of Health and Life Sciences Qatar Foundation Hamad Bin Khalifa University  Doha 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