{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:09:48Z","timestamp":1790388588534,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["NEI R01EY026551"],"award-info":[{"award-number":["NEI R01EY026551"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["R21EY031526"],"award-info":[{"award-number":["R21EY031526"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["210152\/Z\/18\/Z"],"award-info":[{"award-number":["210152\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["UNS35121"],"award-info":[{"award-number":["UNS35121"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000858","name":"University of Sheffield","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000188","name":"Royal Society of Canada","doi-asserted-by":"publisher","award":["UNS35121"],"award-info":[{"award-number":["UNS35121"]}],"id":[{"id":"10.13039\/501100000188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/S010386\/1"],"award-info":[{"award-number":["BB\/S010386\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ageing is a significant risk factor for degeneration of the retina. M\u00fcller glia cells (MG) are key for neuronal regeneration, so harnessing the regenerative capacity of MG in the retina offers great promise for the treatment of age\u2010associated blinding conditions. Yet, the impact of ageing on MG regenerative capacity is unclear. Here, we show that the zebrafish retina undergoes telomerase\u2010independent, age\u2010related neurodegeneration but that this is insufficient to stimulate MG proliferation and regeneration. Instead, age\u2010related neurodegeneration is accompanied by MG morphological aberrations and loss of vision. Mechanistically, yes\u2010associated protein (Yap), part of the Hippo signalling, has been shown to be critical for the regenerative response in the damaged retina, and we show that Yap expression levels decline with ageing. Despite this, morphologically and molecularly altered aged MG retain the capacity to regenerate neurons after acute light damage, therefore, highlighting key differences in the MG response to high\u2010intensity acute damage\n                    <jats:italic>versus<\/jats:italic>\n                    chronic neuronal loss in the zebrafish retina.\n                  <\/jats:p>","DOI":"10.1111\/acel.13597","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T07:12:04Z","timestamp":1647933124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["M\u00fcller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3952-8649","authenticated-orcid":false,"given":"Raquel R.","family":"Martins","sequence":"first","affiliation":[{"name":"The Bateson Centre Healthy Lifespan Institute MRC\u2010Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing and Department of Oncology and Metabolism University of Sheffield Medical School  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Zamzam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhani","family":"Tracey\u2010White","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-5360","authenticated-orcid":false,"given":"Mariya","family":"Moosajee","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology University College London  London UK"},{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"},{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"},{"name":"The Francis Crick Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Thummel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-756X","authenticated-orcid":false,"given":"Catarina M.","family":"Henriques","sequence":"additional","affiliation":[{"name":"The Bateson Centre Healthy Lifespan Institute MRC\u2010Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing and Department of Oncology and Metabolism University of Sheffield Medical School  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-8925","authenticated-orcid":false,"given":"Ryan\u00a0B.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13536"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.011635"},{"key":"e_1_2_11_4_1","first-page":"23","article-title":"A simple grating test for contrast sensitivity: Preliminary results indicate value in screening for glaucoma","volume":"17","author":"Arden G. B.","year":"1978","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.064"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3145re8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1624-07.2007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.07.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328979"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10545"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800175121"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005798"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23601"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00830-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.268897"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S100042"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19878"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0335"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44601"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.131094"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0332-06.2006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-21-09387.2002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22572"},{"key":"e_1_2_11_24_1","first-page":"1205","article-title":"Role of Muller glia in neuroprotection and regeneration in the retina","volume":"18","author":"Garcia M.","year":"2003","journal-title":"Histology and Histopathology"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3723"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200509000-00005"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.045"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-21366"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007939"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003214"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.09.007"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00296"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.05.002"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/293141a0"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23283"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.01.075"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980511)394:3<271::AID-CNE1>3.0.CO;2-Z"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807453105"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.68"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.12.007"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213960"},{"key":"e_1_2_11_42_1","volume-title":"Neuroprotection","author":"Lo S. N. a. A. C. Y.","year":"2019"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22846"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1987.47"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1185-6"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41298-8"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22243"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3838-12.2013"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21721"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-19-08603.1999"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402129101"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0163"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5646"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.02.007"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-6-36"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22477"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00072-8"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.047"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.040857"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.1.21"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1950.00910010475007"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.06.006"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-9994-9-10"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1134\/S000629791809002X"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.02.004"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.09.017"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20596"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-018-9780-6"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1474"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2016.05.009"},{"key":"e_1_2_11_71_1","first-page":"36","article-title":"Senile changes in visual acuity","volume":"95","author":"Weale R. A.","year":"1975","journal-title":"Transactions of the Ophthalmological Societies of the United Kingdom"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617721114"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.13597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T05:26:04Z","timestamp":1692941164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.13597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/acel.13597"],"URL":"https:\/\/doi.org\/10.1111\/acel.13597","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.28.174821","asserted-by":"object"}]},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,22]]},"assertion":[{"value":"2021-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13597"}}