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A considerable amount of segregation errors in humans are introduced at the second meiotic division. We have here compared the chromosome segregation process in young adult and aged female mice during the second meiotic division. More than half of the oocytes in aged mice displayed chromosome segregation irregularities at anaphase II, resulting in dramatically increased level of aneuploidy in haploid gametes, from 4% in young adult mice to 30% in aged mice. We find that the post\u2010metaphase II process that efficiently corrects aberrant kinetochore\u2010microtubule attachments in oocytes in young adult mice is approximately 10\u2010fold less efficient in aged mice, in particular affecting chromosomes that show small inter\u2010centromere distances at the metaphase II stage in aged mice. Our results reveal that post\u2010metaphase II processes have critical impact on age\u2010dependent aneuploidy in mammalian eggs.<\/jats:p>","DOI":"10.1111\/acel.13649","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T19:30:52Z","timestamp":1654284652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Age\u2010dependent aneuploidy in mammalian oocytes instigated at the second meiotic division"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-4567","authenticated-orcid":false,"given":"Anna","family":"Kouznetsova","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Guo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology Karolinska Institutet  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