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Recently, emerging evidence has shown that RNA modifications, which were historically considered infrastructural features of cellular RNAs, are dynamically regulated across most of the RNA species in cells and thereby critically involved in major biological processes, including cellular senescence and aging. In this review, we summarize the current knowledge about RNA modifications and provide a catalog of RNA modifications on different RNA species, including mRNAs, miRNAs, lncRNA, tRNAs, and rRNAs. Most importantly, we focus on the regulation and roles of these RNA modifications in aging\u2010related diseases, including neurodegenerative diseases, cardiovascular diseases, cataracts, osteoporosis, and fertility decline. This would be an important step toward a better understanding of fundamental aging mechanisms and thereby facilitating the development of novel diagnostics and therapeutics for aging\u2010related diseases.<\/jats:p>","DOI":"10.1111\/acel.13657","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:45:27Z","timestamp":1655685927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Regulation and roles of\n                    <scp>RNA<\/scp>\n                    modifications in aging\u2010related diseases"],"prefix":"10.1111","volume":"21","author":[{"given":"Zeyidan","family":"Jiapaer","sequence":"first","affiliation":[{"name":"College of Life Science &amp; Technology Xinjiang University  Urumqi China"},{"name":"Xinjiang Key laboratory of Biological Resources and Genetic Engineering  Urumqi 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