{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:44:08Z","timestamp":1793479448102,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R21 AG054317"],"award-info":[{"award-number":["1R21 AG054317"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AG020719"],"award-info":[{"award-number":["R01 AG020719"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>HIV\u2010positive patients whose viral loads are successfully controlled by active antiretroviral therapy (ART) show no clinical signs of AIDS. However, their lifespan is shorter compared with individuals with no HIV infection and they prematurely exhibit a multitude of chronic diseases typically associated with advanced age. It was hypothesized that immune system aging may correlate with, and provide useful biomarkers for, this premature loss of healthspan in HIV\u2010positive subjects. Here, we tested whether the immune correlates of aging, including cell numbers and phenotypes, inflammatory status, and control of human cytomegalovirus (hCMV) in HIV\u2010positive subjects on long\u2010term successful ART (HIV+) may reveal increased \u201cimmunological age\u201d compared with HIV\u2010negative, age\u2010matched cohort (HIV\u2212) in participants between 50 and 69\u2009years of age. Specifically, we expected that younger HIV+ subjects may immunologically resemble older individuals without HIV. We found no evidence to support this hypothesis. While T cells from HIV+ participants displayed differential expression in several differentiation and\/or inhibitory\/exhaustion markers in different T cell subpopulations, aging by a decade did not pronounce these changes. Similarly, while the HIV+ participants exhibited higher T cell responses and elevated inflammatory marker levels in plasma, indicative of chronic inflammation, this trait was not age\u2010sensitive. We did find differences in immune control of hCMV, and, more importantly, a sustained elevation of sCD14 and of proinflammatory CD4 and CD8 T cell responses across age groups, pointing towards uncontrolled inflammation as a factor in reduced healthspan in successfully treated older HIV+ patients.<\/jats:p>","DOI":"10.1111\/acel.13681","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T02:40:43Z","timestamp":1660704043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Inflammatory and immune markers in\n                    <scp>HIV<\/scp>\n                    \u2010infected older adults on long\u2010term antiretroviral therapy: Persistent elevation of\n                    <scp>sCD14<\/scp>\n                    and of proinflammatory effector memory T cells"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6694-3066","authenticated-orcid":false,"given":"Makiko","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Immunobiology University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7630-1219","authenticated-orcid":false,"given":"Mladen","family":"Jergovic","sequence":"additional","affiliation":[{"name":"Department of Immunobiology University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Immunobiology University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie J.","family":"LaFleur","sequence":"additional","affiliation":[{"name":"BIO5 Institute University of Arizona  Tucson Arizona USA"},{"name":"R. Ken Coit College of Pharmacy Univeristy of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Castaneda","sequence":"additional","affiliation":[{"name":"Department of Immunobiology University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Immunobiology University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Smithey","sequence":"additional","affiliation":[{"name":"Department of Immunobiology University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond P.","family":"Stowe","sequence":"additional","affiliation":[{"name":"Microgen Laboratories  La Marque Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-4300","authenticated-orcid":false,"given":"Elias K.","family":"Haddad","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine, Department of Medicine Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janko","family":"Nikolich\u2010\u017dugich","sequence":"additional","affiliation":[{"name":"Department of Immunobiology University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"Arizona Center on Aging University of Arizona College of Medicine\u2010Tucson  Tucson Arizona USA"},{"name":"BIO5 Institute University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu869"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.12.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.12.015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1316"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir520"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/340508"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501524"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95726"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.2.84"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.03.024"},{"key":"e_1_2_11_15_1","first-page":"10","article-title":"Biomarkers 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