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For example, the variety of molecular mechanisms mediating this infection, and the long\u2010term consequences of the disease remain poorly understood. It first seemed like the SARS\u2010CoV\u20102 infection primarily caused a serious respiratory syndrome. However, over the last years, an increasing number of studies also pointed towards the damaging effects of this infection has on the central nervous system (CNS). In fact, evidence suggests a possible disruption of the blood\u2013brain barrier and deleterious effects on the CNS, especially in patients who already suffer from other pathologies, such as neurodegenerative disorders. The molecular mechanisms behind these effects on the CNS could involve the dysregulation of mitochondrial physiology, a well\u2010known early marker of neurodegeneration and a hallmark of aging. Moreover, mitochondria are involved in the activation of the inflammatory response, which has also been broadly described in the CNS in COVID\u201019. Here, we critically review the current bibliography regarding the presence of neurodegenerative symptoms in COVID\u201019 patients, with a special emphasis on the mitochondrial mechanisms of these disorders.<\/jats:p>","DOI":"10.1111\/acel.13727","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T16:05:58Z","timestamp":1665504358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<scp>COVID<\/scp>\u201019 and neurodegeneration: The mitochondrial connection"],"prefix":"10.1111","volume":"21","author":[{"given":"Christopher A.","family":"Denaro","sequence":"first","affiliation":[{"name":"Department of Biology and Center for Computational and Integrative Biology Rutgers University  Camden New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara I.","family":"Haloush","sequence":"additional","affiliation":[{"name":"Department of Biology and Center for 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