{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:37:35Z","timestamp":1793129855199,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["BX004492"],"award-info":[{"award-number":["BX004492"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T35 DK103596"],"award-info":[{"award-number":["T35 DK103596"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK112826"],"award-info":[{"award-number":["DK112826"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK108833"],"award-info":[{"award-number":["DK108833"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG048366"],"award-info":[{"award-number":["AG048366"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG050238"],"award-info":[{"award-number":["AG050238"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG060395"],"award-info":[{"award-number":["AG060395"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K08AG070281"],"award-info":[{"award-number":["K08AG070281"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aging results in an elevated burden of senescent cells, senescence\u2010associated secretory phenotype (SASP), and tissue infiltration of immune cells contributing to chronic low\u2010grade inflammation and a host of age\u2010related diseases. Recent evidence suggests that the clearance of senescent cells alleviates chronic inflammation and its associated dysfunction and diseases. However, the effect of this intervention on metabolic function in old age remains poorly understood. Here, we demonstrate that dasatinib and quercetin (D&amp;Q) have senolytic effects, reducing age\u2010related increase in senescence\u2010associated \u03b2\u2010galactosidase, expression of\n                    <jats:italic>p16<\/jats:italic>\n                    and\n                    <jats:italic>p21<\/jats:italic>\n                    gene and P16 protein in perigonadal white adipose tissue (pgWAT; all\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2264\u20090.04). This treatment also suppressed age\u2010related increase in the expression of a subset of pro\u2010inflammatory SASP genes (\n                    <jats:italic>mcp1, tnf\u2010\u03b1, il\u20101\u03b1, il\u20101\u03b2, il\u20106, cxcl2,<\/jats:italic>\n                    and\n                    <jats:italic>cxcl10<\/jats:italic>\n                    ), crown\u2010like structures, abundance of T cells and macrophages in pgWAT (all\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2264\u20090.04). In the liver and skeletal muscle, we did not find a robust effect of D&amp;Q on senescence and inflammatory SASP markers. Although we did not observe an age\u2010related difference in glucose tolerance, D&amp;Q treatment improved fasting blood glucose (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.001) and glucose tolerance (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.007) in old mice that was concomitant with lower hepatic gluconeogenesis. Additionally, D&amp;Q improved insulin\u2010stimulated suppression of plasma NEFAs (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.01), reduced fed and fasted plasma triglycerides (both\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2264\u20090.04), and improved systemic lipid tolerance (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.006). Collectively, results from this study suggest that D&amp;Q attenuates adipose tissue inflammation and improves systemic metabolic function in old age. These findings have implications for the development of therapeutic agents to combat metabolic dysfunction and diseases in old age.\n                  <\/jats:p>","DOI":"10.1111\/acel.13767","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T11:57:54Z","timestamp":1673611074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":316,"title":["Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-0628","authenticated-orcid":false,"given":"Md Torikul","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Nutrition and Integrative Physiology The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Tuday","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center Veteran's Affairs Medical Center\u2010Salt Lake City  Salt Lake City Utah USA"},{"name":"Division of Cardiology, Department of Internal Medicine The University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanena","family":"Allen","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center Veteran's Affairs Medical Center\u2010Salt Lake City  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kim","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center Veteran's Affairs Medical Center\u2010Salt Lake City  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Trott","sequence":"additional","affiliation":[{"name":"Department of Kinesiology The University of Texas at Arlington  Arlington Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology The University of Utah  Salt Lake City Utah USA"},{"name":"Geriatric Research Education and Clinical Center Veteran's Affairs Medical Center\u2010Salt Lake City  Salt Lake City Utah USA"},{"name":"Division of Geriatrics, Department of Internal Medicine The University of Utah School of Medicine  Salt Lake City Utah USA"},{"name":"Department of Biochemistry The University of Utah  Salt Lake City Utah USA"},{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Lesniewski","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology The University of Utah  Salt Lake City Utah USA"},{"name":"Geriatric Research Education and Clinical Center Veteran's Affairs Medical Center\u2010Salt Lake City  Salt Lake City Utah USA"},{"name":"Division of Geriatrics, Department of Internal Medicine The University of Utah School of Medicine  Salt Lake City Utah USA"},{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute The University of Utah  Salt Lake City Utah 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