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Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro\u2010inflammatory immune response against SARS\u2010CoV\u20102. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID\u201019 in some cases. Using the established COVID\u201019 murine model K18\u2010hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D\/Q) significantly reduced SARS\u2010CoV\u20102\u2010related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS\u2010CoV\u20102 may be related to the post\u2010COVID\u201019 sequelae described to date. 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