{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:59:19Z","timestamp":1788173959231,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG067988"],"award-info":[{"award-number":["P30AG067988"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R21NR018963\u201001A1S1"],"award-info":[{"award-number":["R21NR018963\u201001A1S1"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Telomere attrition is one of biological aging hallmarks and may be intervened to target multiple aging\u2010related diseases, including Alzheimer's disease and Alzheimer's disease related dementias (AD\/ADRD). The objective of this study was to assess associations of leukocyte telomere length (TL) with AD\/ADRD and early markers of AD\/ADRD, including cognitive performance and brain magnetic resonance imaging (MRI) phenotypes. Data from European\u2010ancestry participants in the UK Biobank (<jats:italic>n<\/jats:italic>\u00a0=\u2009435,046) were used to evaluate whether mid\u2010life leukocyte TL is associated with incident AD\/ADRD over a mean follow\u2010up of 12.2\u2009years. In a subsample without AD\/ADRD and with brain imaging data (<jats:italic>n<\/jats:italic>\u00a0=\u200943,390), we associated TL with brain MRI phenotypes related to AD or vascular dementia pathology. Longer TL was associated with a lower risk of incident AD\/ADRD (adjusted Hazard Ratio [aHR] per SD\u00a0=\u00a00.93, 95% CI 0.90\u20130.96, <jats:italic>p<\/jats:italic>\u00a0=\u20093.37\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>). Longer TL also was associated with better cognitive performance in specific cognitive domains, larger hippocampus volume, lower total volume of white matter hyperintensities, and higher fractional anisotropy and lower mean diffusivity in the fornix. In conclusion, longer TL is inversely associated with AD\/ADRD, cognitive impairment, and brain structural lesions toward the development of AD\/ADRD. However, the relationships between genetically determined TL and the outcomes above were not statistically significant based on the results from Mendelian randomization analysis results. Our findings add to the literature of prioritizing risk for AD\/ADRD. The causality needs to be ascertained in mechanistic studies.<\/jats:p>","DOI":"10.1111\/acel.13808","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T05:47:03Z","timestamp":1685512023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Mid\u2010life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 <scp>UK<\/scp> Biobank participants"],"prefix":"10.1111","volume":"22","author":[{"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Health Sciences Sacred Heart University  Fairfield Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiruo","family":"Xiang","sequence":"additional","affiliation":[{"name":"Connecticut Convergence Institute for Translation in Regenerative Engineering University of Connecticut Health  Farmington Connecticut 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