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In the realm of sporadic tauopathies, modelling the process of biological ageing in experimental animals forms the foundation of searching for the molecular origin of pathogenic tau and developing potential therapeutic interventions. Although prior research into transgenic tau models offers valuable lessons for studying how tau mutations and overexpression can drive tau pathologies, the underlying mechanisms by which ageing leads to abnormal tau accumulation remains poorly understood. Mutations associated with human progeroid syndromes have been proposed to be able to mimic an aged environment in animal models. Here, we summarise recent attempts in modelling ageing in relation to tauopathies using animal models that carry mutations associated with human progeroid syndromes, or genetic elements unrelated to human progeroid syndromes, or have exceptional natural lifespans, or a remarkable resistance to ageing\u2010related disorders.<\/jats:p>","DOI":"10.1111\/acel.13830","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T02:12:43Z","timestamp":1680574363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Can accelerated ageing models inform us on age\u2010related tauopathies?"],"prefix":"10.1111","volume":"22","author":[{"given":"Zhuang Zhuang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of Cambridge  Tennis Ct Rd Cambridge CB2 1PD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3225-4163","authenticated-orcid":false,"given":"Alex","family":"Fleet","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Cambridge  Tennis Ct Rd Cambridge CB2 1PD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-9361","authenticated-orcid":false,"given":"Delphine","family":"Larrieu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Cambridge  Tennis Ct Rd Cambridge CB2 1PD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1389","article-title":"Structure of the bovine tau gene: Alternatively spliced transcripts generate a protein family","volume":"9","author":"Adolf H.","year":"1989","journal-title":"Molecular and Cellular Biology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12373"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-21-09340.2002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.041"},{"key":"e_1_2_9_6_1","unstructured":"ALZFORUM \u2013 Animal Models Animal Models. 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