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Hence, it is an organ of choice to investigate cellular senescence and to target root\u2010cause aging processes using senolytic and senomorphic agents, including naturally occurring plant\u2010based derivatives. This review presents different aspects of skin cellular senescence, from physiology to pathology and signaling pathways. Cellular senescence can have both beneficial and detrimental effects on the skin, indicating that both prosenescent and antisenescent therapies may be desirable, based on the context. Knowledge of molecular mechanisms involved in skin cellular senescence may provide meaningful insights for developing effective therapeutics for senescence\u2010related skin disorders, such as wound healing and cosmetic skin aging changes.<\/jats:p>","DOI":"10.1111\/acel.13845","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T06:40:08Z","timestamp":1681281608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Cellular senescence in skin\u2010related research: Targeted signaling pathways and naturally occurring therapeutic agents"],"prefix":"10.1111","volume":"22","author":[{"given":"Aleksandra","family":"Da\u0144czak\u2010Pazdrowska","sequence":"first","affiliation":[{"name":"Department of Dermatology Poznan University of Medical Sciences  Poznan 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