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In several eukaryotic phyla, ACBP\/DBI transcends its intracellular function in fatty acid metabolism because it can be released into the extracellular space. This ACBP\/DBI secretion usually occurs in response to nutrient scarcity through an autophagy\u2010dependent pathway. ACBP\/DBI and its peptide fragments then act on a range of distinct receptors that diverge among phyla, namely metabotropic G protein\u2010coupled receptor in yeast (and likely in the mammalian central nervous system), a histidine receptor kinase in slime molds, and ionotropic gamma\u2010aminobutyric acid (GABA)\n                    <jats:sub>A<\/jats:sub>\n                    receptors in mammals. Genetic or antibody\u2010mediated inhibition of ACBP\/DBI orthologs interferes with nutrient stress\u2010induced adaptations such as sporulation or increased food intake in multiple species, as it enhances lifespan or healthspan in yeast, plant leaves, nematodes, and multiple mouse models. These lifespan and healthspan\u2010extending effects of ACBP\/DBI suppression are coupled to the induction of autophagy. Altogether, it appears that neutralization of extracellular ACBP\/DBI results in \u201cautophagy checkpoint inhibition\u201d to unleash the anti\u2010aging potential of autophagy. Of note, in humans, ACBP\/DBI levels increase in various tissues, as well as in the plasma, in the context of aging, obesity, uncontrolled infection or cardiovascular, inflammatory, neurodegenerative, and malignant diseases.\n                  <\/jats:p>","DOI":"10.1111\/acel.13910","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T06:10:59Z","timestamp":1687759859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Acyl coenzyme A binding protein (\n                    <scp>ACBP<\/scp>\n                    ): An aging\u2010 and disease\u2010relevant \u201cautophagy checkpoint\u201d"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4778-4757","authenticated-orcid":false,"given":"L\u00e9a","family":"Mont\u00e9gut","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers, Equipe labellis\u00e9e par la Ligue Contre le 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