{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:21:31Z","timestamp":1783948891746,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 35\/1503\u20101 FUGG"],"award-info":[{"award-number":["INST 35\/1503\u20101 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["259332240"],"award-info":[{"award-number":["259332240"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["394046768"],"award-info":[{"award-number":["394046768"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["5454871"],"award-info":[{"award-number":["5454871"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["5486332"],"award-info":[{"award-number":["5486332"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 35\/1314\u20101 FUGG"],"award-info":[{"award-number":["INST 35\/1314\u20101 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stabilin\u20101 (Stab1) and Stabilin\u20102 (Stab2) are two major scavenger receptors of liver sinusoidal endothelial cells that mediate removal of diverse molecules from the plasma. Double\u2010knockout mice (Stab\u2010DKO) develop impaired kidney function and a decreased lifespan, while single Stabilin deficiency or therapeutic inhibition ameliorates atherosclerosis and Stab1\u2010inhibition is subject of clinical trials in immuno\u2010oncology. Although POSTN and TFGBI have recently been described as novel Stabilin ligands, the dynamics and functional implications of these ligands have not been comprehensively studied. Immunofluorescence, Western Blotting and Simple Western\u2122 as well as in situ hybridization (RNAScope\u2122) and qRT\u2010PCR were used to analyze transcription levels and tissue distribution of POSTN and TGFBI in Stab\u2010KO mice. Stab\u2010POSTN\u2010Triple deficient mice were generated to assess kidney and liver fibrosis and function in young and aged mice. TGFBI and POSTN protein accumulated in liver tissue in Stab\u2010DKO mice and age\u2010dependent in glomeruli of Stabilin\u2010deficient mice despite unchanged transcriptional levels. Stab\u2010POSTN\u2010Triple KO mice showed glomerulofibrosis and a reduced lifespan comparable to Stab\u2010DKO mice. However, alterations of the glomerular diameter and vascular density were partially normalized in Stab\u2010POSTN\u2010Triple KO. TGFBI and POSTN are Stabilin\u2010ligands that are deposited in an age\u2010dependent manner in the kidneys and liver due to insufficient scavenging in the liver. Functionally, POSTN might partially contribute to the observed renal phenotype in Stab\u2010DKO mice. This study provides details on downstream effects how Stabilin dysfunction affects organ function on a molecular and functional level.<\/jats:p>","DOI":"10.1111\/acel.13914","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T01:26:35Z","timestamp":1687742795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Deficiency for scavenger receptors Stabilin\u20101 and Stabilin\u20102 leads to age\u2010dependent renal and hepatic depositions of fasciclin domain proteins\n                    <scp>TGFBI<\/scp>\n                    and Periostin in mice"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7157-1201","authenticated-orcid":false,"given":"Thomas","family":"Leibing","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Section of Clinical and Molecular Dermatology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Section of Clinical and Molecular Dermatology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Section of Clinical and Molecular Dermatology, University Medical Center and Medical 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Kirkamm","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Section of Clinical and Molecular Dermatology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Dormann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Section of Clinical and Molecular Dermatology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Schledzewski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergij","family":"Goerdt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"European Center for Angioscience (ECAS), Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrill","family":"G\u00e9raud","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University  Mannheim 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