{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:23:10Z","timestamp":1788992590492,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1K01AG075180\u201001"],"award-info":[{"award-number":["1K01AG075180\u201001"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010983"],"award-info":[{"award-number":["2021A1515010983"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The fluctuations in resting\u2010state beat\u2010to\u2010beat blood pressure (BP) are physiologically complex, and the degree of such BP complexity is believed to reflect the multiscale regulation of this critical physiologic process. Hypertension (HTN), one common age\u2010related condition, is associated with altered BP regulation and diminished system responsiveness to perturbations such as orthostatic change. We thus aimed to characterize the impact of HTN on resting\u2010state BP complexity, as well as the relationship between BP complexity and both adaptive capacity and underlying vascular characteristics. We recruited 392 participants (age: 60\u201391\u2009years), including 144 that were normotensive and 248 with HTN (140 controlled\u2010 and 108 uncontrolled\u2010HTN). Participants completed a 10\u2010min continuous finger BP recording during supine rest, then underwent measures of lying\u2010to\u2010standing BP change, arterial stiffness (i.e., brachial\u2010ankle pulse wave velocity), and endothelial function (i.e., flow\u2010mediated vasodilation). The complexity of supine beat\u2010to\u2010beat systolic (SBP) and diastolic (DBP) BP was quantified using multiscale entropy. Thirty participants with HTN (16 controlled\u2010HTN and 14 uncontrolled\u2010HTN) exhibited orthostatic hypotension. SBP and DBP complexity was greatest in normotensive participants, lower in those with controlled\u2010HTN, and lowest in those in uncontrolled\u2010HTN (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005). Lower SBP and DBP complexity correlated with greater lying\u2010to\u2010standing decrease in SBP and DBP level (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.33 to \u22120.19, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), greater arterial stiffness (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.35 to \u22120.18, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and worse endothelial function (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.17\u20130.22, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), both across all participants and within the control\u2010 and uncontrolled\u2010HTN groups. These results suggest that in older adults, BP complexity may capture the integrity of multiple interacting physiologic mechanisms that regulate BP and are important to cardiovascular health.<\/jats:p>","DOI":"10.1111\/acel.13943","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:33:27Z","timestamp":1692873207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The physiologic complexity of beat\u2010to\u2010beat blood pressure is associated with age\u2010related alterations in blood pressure regulation"],"prefix":"10.1111","volume":"23","author":[{"given":"Xin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Mang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shenzhen People's Hospital  Shenzhen China"},{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis A.","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research Hebrew SeniorLife  Boston Massachusetts USA"},{"name":"Division of Gerontology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Manor","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research Hebrew SeniorLife  Boston Massachusetts USA"},{"name":"Division of Gerontology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Jinan University  Shenzhen China"},{"name":"The First Affiliated Hospital Southern University of Science and Technology  Shenzhen China"},{"name":"Department of Neurology Shenzhen People's Hospital  Shenzhen China"},{"name":"Shenzhen Bay Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7931-7646","authenticated-orcid":false,"given":"Junhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research Hebrew SeniorLife  Boston Massachusetts USA"},{"name":"Division of Gerontology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2930625"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpy089"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.89.068102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.71.021906"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.06.080"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010010\u20100150\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2008.0274"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.11.024"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.10.2307"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd9.110037"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010011\u20100119\u20105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000002030"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13996"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(01)00266\u20104"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282fe1d28"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24393"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.109.140665VV"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010999\u20100030\u20109"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.833125"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac035"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.640942"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.636702"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19113"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.224"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000615"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517\u2010014\u20101216\u20100"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198910053211407"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480130122036"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12288"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13521"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.08.020"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.99"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100838.2011.01435.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.11.003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490080086030"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010022\u201000447\u20108"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.117.09097"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109343(99)00425\u20108"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/356168a0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(05)70141\u20101"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly061"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03617"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.29.3.736"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00471.2010"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00581.2016"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.103"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(03)00994\u2010x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005\u20102586"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.615"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.359"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201003422\u20104"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12984\u2010016\u20100152\u20107"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134775"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T20:13:39Z","timestamp":1705695219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.13943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/acel.13943"],"URL":"https:\/\/doi.org\/10.1111\/acel.13943","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,24]]},"assertion":[{"value":"2023-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13943"}}