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Patients with BSyn present with poor growth, sun sensitivity, mild immunodeficiency, diabetes, and increased risk of cancer, most commonly leukemias. Interestingly, patients with BSyn do not have other signs of premature aging such as early, progressive hair loss and cataracts. We set out to determine epigenetic age in BSyn, which can be a better predictor of health and disease over chronological age. Our results show for the first time that patients with BSyn have evidence of accelerated epigenetic aging across several measures in blood lymphocytes, as compared to carriers. Additionally, homozygous <jats:italic>Blm<\/jats:italic> mice exhibit accelerated methylation age in multiple tissues, including brain, blood, kidney, heart, and skin, according to the brain methylation clock. Overall, we find that Bloom syndrome is associated with accelerated epigenetic aging effects in multiple tissues and more generally a strong effect on CpG methylation levels.<\/jats:p>","DOI":"10.1111\/acel.13964","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:33:04Z","timestamp":1692646384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bloom syndrome patients and mice display accelerated epigenetic aging"],"prefix":"10.1111","volume":"22","author":[{"given":"Jamie","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-1175","authenticated-orcid":false,"given":"Joshua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Human Genetics UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-6949","authenticated-orcid":false,"given":"Julian A.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Human Genetics UCLA  Los Angeles California USA"},{"name":"Division of Medical Genetics UCLA  Los Angeles California USA"},{"name":"Department of Psychiatry UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-477X","authenticated-orcid":false,"given":"Christopher","family":"Cunniff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4865-4033","authenticated-orcid":false,"given":"Nicole","family":"Kucine","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-7961","authenticated-orcid":false,"given":"Ake T.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Human Genetics UCLA  Los Angeles California USA"},{"name":"Altos Labs  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-8793","authenticated-orcid":false,"given":"Amin","family":"Haghani","sequence":"additional","affiliation":[{"name":"Department of Human Genetics UCLA  Los Angeles California USA"},{"name":"Altos Labs  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-6721","authenticated-orcid":false,"given":"Juozas","family":"Gordevi\u010dius","sequence":"additional","affiliation":[{"name":"The Epigenetic Clock Development Foundation  Torrance California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-3589","authenticated-orcid":false,"given":"Steve","family":"Horvath","sequence":"additional","affiliation":[{"name":"Department of Human Genetics UCLA  Los Angeles California USA"},{"name":"Altos Labs  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-1500","authenticated-orcid":false,"given":"Vivian Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology UCLA  Los Angeles California USA"},{"name":"Children's Discovery and Innovation Institute UCLA  Los Angeles California USA"},{"name":"Jonsson Comprehensive Cancer Center UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103819"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157\u20107412.1000177"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20104608(99)00099\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omy096"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.09.079"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028355\u2010z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks407"},{"issue":"12","key":"e_1_2_10_9_1","first-page":"847","article-title":"Prevalence of breast and colorectal cancer in Ashkenazi Jewish carriers of Fanconi anemia and Bloom syndrome","volume":"9","author":"Baris H. 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