{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:52:27Z","timestamp":1776883947584,"version":"3.51.2"},"reference-count":114,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010HL151838"],"award-info":[{"award-number":["R01\u2010HL151838"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While frailty is a prominent risk factor in an aging population, the underlying biology of frailty is incompletely described. Here, we integrate 979 circulating proteins across a wide range of physiologies with 12 measures of frailty in a prospective discovery cohort of 809 individuals with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation. Our aim was to characterize the proteomic architecture of frailty in a highly susceptible population and study its relation to clinical outcome and systems\u2010wide phenotypes to define potential novel, clinically relevant frailty biology. Proteomic signatures (specifically of physical function) were related to post\u2010intervention outcome in AS, specifying pathways of innate immunity, cell growth\/senescence, fibrosis\/metabolism, and a host of proteins not widely described in human aging. In published cohorts, the \u201cfrailty proteome\u201d displayed heterogeneous trajectories across age (20\u2013100\u2009years, age only explaining a small fraction of variance) and were associated with cardiac and non\u2010cardiac phenotypes and outcomes across two broad validation cohorts (<jats:italic>N<\/jats:italic>\u2009&gt;\u200935,000) over \u22482\u20133 decades. These findings suggest the importance of precision biomarkers of underlying multi\u2010organ health status in age\u2010related morbidity and frailty.<\/jats:p>","DOI":"10.1111\/acel.13978","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T04:48:51Z","timestamp":1695271731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Proteomic architecture of frailty across the spectrum of cardiovascular disease"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-6158","authenticated-orcid":false,"given":"Andrew S.","family":"Perry","sequence":"first","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Gajjar","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Section, Department of Medicine Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-1321","authenticated-orcid":false,"given":"Venkatesh L.","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Lehallier","sequence":"additional","affiliation":[{"name":"Alkahest, Inc.  San Carlos California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, and Department of Biostatistics Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Nair","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Neill","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine University of Wisconsin Hospital and Clinics  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Jeffrey","family":"Carr","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Fearon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Stanford Medical Center  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharam","family":"Kumbhani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Gillam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Morristown Medical Center  Morristown New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn","family":"Lindenfeld","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Farrell","sequence":"additional","affiliation":[{"name":"Broad Institute of Harvard and MIT  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan M.","family":"Marron","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-1439","authenticated-orcid":false,"given":"Qu","family":"Tian","sequence":"additional","affiliation":[{"name":"National Institute on Aging, National Institutes of Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Departments of Medicine and Clinical and Translational Science University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Murabito","sequence":"additional","affiliation":[{"name":"Sections of Cardiovascular Medicine and Preventive Medicine and Epidemiology, Department of Medicine Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Gerszten","sequence":"additional","affiliation":[{"name":"Broad Institute of Harvard and MIT  Cambridge Massachusetts USA"},{"name":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Nayor","sequence":"additional","affiliation":[{"name":"Sections of Cardiovascular Medicine and Preventive Medicine and Epidemiology, Department of Medicine Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy","family":"Elmariah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology The University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian R.","family":"Lindman","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Shah","sequence":"additional","affiliation":[{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100719\u20105"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.03.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00058"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604893104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000599"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395\u2010015\u20100047\u20105"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532\u20105415.2003.51465.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.03.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2004.52570.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7791"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)62167\u20109"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101911\u2010y"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2012.04054.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.22540\/JFSF\u201006\u2010225"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573\u2010020\u201000133\u2010w"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27025"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.153"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016\u20101884"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010021\u201002289\u20106"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaq1327"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010021\u201000978\u2010w"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010018\u20100064\u20102"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609243"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.963215"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.110.958884"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78197"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2018.02.002"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102164\u201015\u2010621"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(00)00531\u20103"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503023320902"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.m85"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004611\u2010z"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113720"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102013\u201014\u201010\u2010r115"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312706"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.029"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000690"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920795117"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm5164"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/10.1_part_1.20"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010031388"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.08.015"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.05.014"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026141"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620\u2010014\u20100045\u20104"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000093487.78664.3C"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v028.i05"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010020\u201000288\u20109"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12203"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100673\u20102"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13256"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2017.11.004"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010015\u20109864\u2010z"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111228"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13736"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010021\u201002810\u2010x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvab278"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101784"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt\u20102015\u2010000294"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-47622-9"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123787"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006749"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021803"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201085080\u20101"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.830723"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.4903"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009859"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2006.00701.x"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026529"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9570"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddac275"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/01823246-200819010-00005"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac544.909"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1706234"},{"key":"e_1_2_11_82_1","volume-title":"psych: Procedures for personality and psychological research","author":"Revelle W.","year":"2022"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.10.029"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010018\u20101223\u20103"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201033330\u20100_3"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278\u2010004\u20101014\u20106"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.6.m366"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102826"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13193"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.023"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201611\u20102263OC"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13290"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.043"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2021.11.002"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.038"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251152"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035831"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023466"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115767"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61073"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12799"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa061"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201018\u20100422"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.036"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.12.1393"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1033"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.20.2333"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016171"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150132"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15381"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2009.07.007"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00463.2021"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.13978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T12:17:17Z","timestamp":1700137037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.13978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":114,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/acel.13978"],"URL":"https:\/\/doi.org\/10.1111\/acel.13978","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]},"assertion":[{"value":"2023-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13978"}}