{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:47:46Z","timestamp":1789753666486,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M692241"],"award-info":[{"award-number":["2021M692241"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although immunosenescence may result in increased morbidity and mortality, many mammals have evolved effective immune coping strategies to extend their lifespans. Thus, the immune systems of long\u2010lived mammals present unique models to study healthy longevity. To identify the molecular clues of anti\u2010immunosenescence, we first built high\u2010quality reference genome for a long\u2010lived myotis bat, and then compared three long\u2010lived mammals (i.e., bat, naked mole rat, and human) versus the short\u2010lived mammal, mouse, in splenic immune cells at single\u2010cell resolution. A close relationship between B:T cell ratio and immunosenescence was detected, as B:T cell ratio was much higher in mouse than long\u2010lived mammals and significantly increased during aging. Importantly, we identified several iron\u2010related genes that could resist immunosenescence changes, especially the iron chaperon,\n                    <jats:italic>PCBP1<\/jats:italic>\n                    , which was upregulated in long\u2010lived mammals but dramatically downregulated during aging in all splenic immune cell types. Supportively, immune cells of mouse spleens contained more free iron than those of bat spleens, suggesting higher level of ROS\u2010induced damage in mouse.\n                    <jats:italic>PCBP1<\/jats:italic>\n                    downregulation during aging was also detected in hepatic but not pulmonary immune cells, which is consistent with the crucial roles of spleen and liver in organismal iron recycling. Furthermore,\n                    <jats:italic>PCBP1<\/jats:italic>\n                    perturbation in immune cell lines would result in cellular iron dyshomeostasis and senescence. Finally, we identified two transcription factors that could regulate\n                    <jats:italic>PCBP1<\/jats:italic>\n                    during aging. Together, our findings highlight the importance of iron homeostasis in splenic anti\u2010immunosenescence, and provide unique insight for improving human healthspan.\n                  <\/jats:p>","DOI":"10.1111\/acel.13982","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T06:40:58Z","timestamp":1694155258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cross\u2010species comparison illuminates the importance of iron homeostasis for splenic anti\u2010immunosenescence"],"prefix":"10.1111","volume":"22","author":[{"given":"Ziqing","family":"He","sequence":"first","affiliation":[{"name":"GMU\u2010GIBH Joint School of Life Sciences, The Guangdong\u2010Hong Kong\u2010Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou National Laboratory Guangzhou Medical University  Guangzhou China"},{"name":"Faculty of Health Sciences University of Macau  Macau 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Guangzhou National Laboratory Guangzhou Medical University  Guangzhou China"},{"name":"Faculty of Health Sciences University of Macau  Macau China"},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingpei","family":"Huang","sequence":"additional","affiliation":[{"name":"GMU\u2010GIBH Joint School of Life Sciences, The Guangdong\u2010Hong Kong\u2010Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou National Laboratory Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilue","family":"Chen","sequence":"additional","affiliation":[{"name":"GMU\u2010GIBH Joint School of Life Sciences, The Guangdong\u2010Hong Kong\u2010Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou National Laboratory Guangzhou Medical University  Guangzhou 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