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The accumulation of progerin accelerates the onset of a dramatic premature aging phenotype in children with HGPS, characterized by low body weight, lipodystrophy, metabolic dysfunction, skin, and musculoskeletal age\u2010related dysfunctions. In most cases, these children die of age\u2010related cardiovascular dysfunction by their early teenage years. The absence of effective treatments for HGPS underscores the critical need to explore novel safe therapeutic strategies. In this study, we show that treatment with the hormone ghrelin increases autophagy, decreases progerin levels, and alleviates other cellular hallmarks of premature aging in human HGPS fibroblasts. Additionally, using a HGPS mouse model (\n                    <jats:italic>Lmna<\/jats:italic>\n                    <jats:sup>G609G\/G609G<\/jats:sup>\n                    mice), we demonstrate that ghrelin administration effectively rescues molecular and histopathological progeroid features, prevents progressive weight loss in later stages, reverses the lipodystrophic phenotype, and extends lifespan of these short\u2010lived mice. Therefore, our findings uncover the potential of modulating ghrelin signaling offers new treatment targets and translational approaches that may improve outcomes and enhance the quality of life for patients with HGPS and other age\u2010related pathologies.\n                  <\/jats:p>","DOI":"10.1111\/acel.13983","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:56:01Z","timestamp":1697763361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ghrelin delays premature aging in\n                    <scp>Hutchinson\u2010Gilford<\/scp>\n                    progeria syndrome"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-6411","authenticated-orcid":false,"given":"Marisa","family":"Ferreira\u2010Marques","sequence":"first","affiliation":[{"name":"CNC \u2013 Center for Neuroscience and Cell Biology University of Coimbra  Coimbra 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