{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:58:26Z","timestamp":1780325906002,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG000181"],"award-info":[{"award-number":["AG000181"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG059416"],"award-info":[{"award-number":["AG059416"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Performance fatigability is typically experienced as insufficient energy to complete daily physical tasks, particularly with advancing age, often progressing toward dependency. Thus, understanding the etiology of performance fatigability, especially cellular\u2010level biological mechanisms, may help to delay the onset of mobility disability. We hypothesized that skeletal muscle energetics may be important contributors to performance fatigability. Participants in the Study of Muscle, Mobility and Aging completed a usual\u2010paced 400\u2010m walk wearing a wrist\u2010worn ActiGraph GT9X to derive the Pittsburgh Performance Fatigability Index (PPFI, higher scores\u2009=\u2009more severe fatigability) that quantifies percent decline in individual cadence\u2010versus\u2010time trajectory from their maximal cadence. Complex I&amp;II\u2010supported maximal oxidative phosphorylation (max OXPHOS) and complex I&amp;II\u2010supported electron transfer system (max ETS) were quantified ex\u00a0vivo using high\u2010resolution respirometry in permeabilized fiber bundles from vastus lateralis muscle biopsies. Maximal adenosine triphosphate production (ATP<jats:sub>max<\/jats:sub>) was assessed in\u00a0vivo by <jats:sup>31<\/jats:sup>P magnetic resonance spectroscopy. We conducted tobit regressions to examine associations of max OXPHOS, max ETS, and ATP<jats:sub>max<\/jats:sub> with PPFI, adjusting for technician\/site, demographic characteristics, and total activity count over 7\u2010day free\u2010living among older adults (<jats:italic>N<\/jats:italic>\u2009=\u2009795, 70\u201394\u2009years, 58% women) with complete PPFI scores and \u22651 energetics measure. Median PPFI score was 1.4% [25th\u201375th percentile: 0%\u20132.9%]. After full adjustment, each 1 standard deviation lower max OXPHOS, max ETS, and ATP<jats:sub>max<\/jats:sub> were associated with 0.55 (95% CI: 0.26\u20130.84), 0.39 (95% CI: 0.09\u20130.70), and 0.54 (95% CI: 0.27\u20130.81) higher PPFI score, respectively. Our findings suggested that therapeutics targeting muscle energetics may potentially mitigate fatigability and lessen susceptibility to disability among older adults.<\/jats:p>","DOI":"10.1111\/acel.14015","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T15:32:28Z","timestamp":1697470348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Associations between skeletal muscle energetics and accelerometry\u2010based performance fatigability: Study of Muscle, Mobility and Aging"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-3320","authenticated-orcid":false,"given":"Yujia (Susanna)","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-2909","authenticated-orcid":false,"given":"Adam J.","family":"Santanasto","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-2115","authenticated-orcid":false,"given":"Paul M.","family":"Coen","sequence":"additional","affiliation":[{"name":"AdventHealth, Translational Research Institute  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy M.","family":"Cawthon","sequence":"additional","affiliation":[{"name":"San Francisco Coordinating Center California Pacific Medical Center Research Institute  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics, School of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Cummings","sequence":"additional","affiliation":[{"name":"San Francisco Coordinating Center California Pacific Medical Center Research Institute  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics, School of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Medicine (Geriatrics and Cardiology) University of Pittsburgh, and Geriatrics, Research, Education, and Clinical Center (GRECC), VA Pittsburgh Healthcare System  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret H.","family":"Goodpaster","sequence":"additional","affiliation":[{"name":"AdventHealth, Translational Research Institute  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Harezlak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health\u2010Bloomington Indiana University  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marquis","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Gerontology and Geriatric Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Nicklas","sequence":"additional","affiliation":[{"name":"Gerontology and Geriatric Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico G. 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