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Dermal aging is distinguished by reduced dermal thickness, increased wrinkles, and a sagging appearance. Due to intrinsic or extrinsic factors, accumulation of excessive reactive oxygen species (ROS) triggers a series of aging events, including imbalanced extracellular matrix (ECM) homeostasis, accumulation of senescent fibroblasts, loss of cell identity, and chronic inflammation mediated by senescence\u2010associated secretory phenotype (SASP). These events are regulated by signaling pathways, such as nuclear factor erythroid 2\u2010related factor 2 (Nrf2), mechanistic target of rapamycin (mTOR), transforming growth factor beta (TGF\u2010\u03b2), and insulin\u2010like growth factor 1 (IGF\u20101). Senescent fibroblasts can induce and accelerate age\u2010related dysfunction of other skin cells and may even cause systemic inflammation. In this review, we summarize the role of dermal fibroblasts in cutaneous aging and inflammation. Moreover, the underlying mechanisms by which dermal fibroblasts influence cutaneous aging and inflammation are also discussed.<\/jats:p>","DOI":"10.1111\/acel.14054","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T07:15:26Z","timestamp":1701501326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":232,"title":["Aging in the dermis: Fibroblast senescence and its significance"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7525-2075","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Immunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Tianjin Medical University  Tianjin 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