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We show that in the highly regenerative <jats:italic>Drosophila<\/jats:italic> testis, <jats:italic>miR\u201034<\/jats:italic> levels are significantly elevated during aging. <jats:italic>miR\u201034<\/jats:italic> modulates germ cell death and protects the progenitor germ cells from accelerated aging. However, <jats:italic>miR\u201034<\/jats:italic> is not expressed in the progenitors themselves but rather in neighboring cyst cells that kill the progenitors. Transcriptomics followed by functional analysis revealed that during aging, <jats:italic>miR\u201034<\/jats:italic> modifies integrin signaling by limiting the levels of the heterodimeric integrin receptor \u03b1PS2 and \u03b2PS subunits. In addition, we found that in cyst cells, this heterodimer is essential for inducing phagoptosis and degradation of the progenitor germ cells. Together, these data suggest that the <jats:italic>miR\u201034<\/jats:italic>\u2014integrin signaling axis acts as a sensor of progenitor germ cell death to extend progenitor functionality during aging.<\/jats:p>","DOI":"10.1111\/acel.14131","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:23:05Z","timestamp":1709810585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Integrin restriction by <i>miR\u201034<\/i> protects germline progenitors from cell death during aging"],"prefix":"10.1111","volume":"23","author":[{"given":"Noam","family":"Perry","sequence":"first","affiliation":[{"name":"Department of Human Biology, Faculty of Natural Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racheli","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Natural Sciences University of Haifa  Haifa Israel"},{"name":"Biomedical Engineering Faculty Technion IITs  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Ben\u2010Hamo\u2010Arad","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Natural Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kanaan","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Natural Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Arad","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Natural Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach","family":"Porat\u2010Kuperstein","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Natural Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-7728","authenticated-orcid":false,"given":"Hila","family":"Toledano","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Natural Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1825"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"7","article-title":"The haemopoietic stem cell: Between apoptosis and self renewal","volume":"82","author":"Alenzi F. 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