{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:47:33Z","timestamp":1791604053589,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since their introduction, epigenetic clocks have been extensively used in aging, human disease, and rejuvenation studies. In this article, we report an intriguing pattern: epigenetic age predictions display a 24\u2010h periodicity. We tested a circadian blood sample collection using 17 epigenetic clocks addressing different aspects of aging. Thirteen clocks exhibited significant oscillations with the youngest and oldest age estimates around midnight and noon, respectively. In addition, daily oscillations were consistent with the changes of epigenetic age across different times of day observed in an independant populational dataset. While these oscillations can in part be attributed to variations in white blood cell type composition, cell count correction methods might not fully resolve the issue. Furthermore, some epigenetic clocks exhibited 24\u2010h periodicity even in the purified fraction of neutrophils pointing at plausible contributions of intracellular epigenomic oscillations. Evidence for circadian variation in epigenetic clocks emphasizes the importance of the time\u2010of\u2010day for obtaining accurate estimates of epigenetic age.<\/jats:p>","DOI":"10.1111\/acel.14170","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T05:40:08Z","timestamp":1713505208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Epigenetic age oscillates during the day"],"prefix":"10.1111","volume":"23","author":[{"given":"Karolis","family":"Koncevi\u010dius","sequence":"first","affiliation":[{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-6105","authenticated-orcid":false,"given":"Akhil","family":"Nair","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University  Vilnius Lithuania"},{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Au\u0161rin\u0117","family":"\u0160veikauskait\u0117","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u0117","family":"\u0160e\u0161tokait\u0117","sequence":"additional","affiliation":[{"name":"Laboratory for Genetic Diagnostics National Cancer Institute  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auks\u0117","family":"Kazlauskait\u0117","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrius","family":"Dulskas","sequence":"additional","affiliation":[{"name":"Department of Abdominal and General Surgery and Oncology National Cancer Institute  Vilnius Lithuania"},{"name":"Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Art\u016bras","family":"Petronis","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Life Sciences Center, Vilnius University  Vilnius Lithuania"},{"name":"The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2023.2230686"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00576"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu049"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"Belsky D. W. Caspi A. Corcoran D. L. Sugden K. Poulton R. Arseneault L. Baccarelli A. Chamarti K. Gao X. Hannon E. Harrington H. L. Houts R. Kothari M. Kwon D. Mill J. Schwartz J. Vokonas P. Wang C. Williams B. S. &Moffitt T. E.(2022).DunedinPACE a DNA methylation biomarker of the pace of aging.","DOI":"10.1101\/2021.08.30.21262858"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-023-01161-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.9.4454"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4682-11-16"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31189"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-0215-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0503-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-017-0001-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2021.101917"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0615-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00248-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1030-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0004-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-86"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067378"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101414"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100908"},{"key":"e_1_2_8_25_1","first-page":"9484","article-title":"DNA methylation GrimAge version 2","volume":"14","author":"Lu A. T.","year":"2022","journal-title":"Aging"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00462-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101684"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102173"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","unstructured":"McGreevy K. M. Radak Z. Torma F. Jokai M. Lu A. T. Belsky D. W. Binder A. Marioni R. E. Ferrucci L. Po\u015bpiech E. Branicki W. Ossowski A. Sitek A. Sp\u00f3lnicka M. Raffield L. M. Reiner A. P. Cox S. Kobor M. Corcoran D. L. &Horvath S.(2023).DNAmFitAge: Biological age indicator incorporating physical fitness 15 3904\u20133938.","DOI":"10.18632\/aging.204538"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101348"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1608-9"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041361"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.117.001937"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27864-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00752-3"},{"key":"e_1_2_8_37_1","article-title":"R methylCIPHER: A Methylation Clock Investigational Package for Hypothesis\u2010Driven Evaluation & Research","author":"Thrush K. L.","year":"2022","journal-title":"bioRxiv"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt090"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00126"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-023-01507-8"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-2-r24"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1064-3"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2017.1389361"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0667-1"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14617"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.14170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:20:51Z","timestamp":1721377251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.14170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/acel.14170"],"URL":"https:\/\/doi.org\/10.1111\/acel.14170","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]},"assertion":[{"value":"2023-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14170"}}