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UVB causes skin injury through the generation of free radicals and other oxidative byproducts, also contributing to DNA damage. Appearance and accumulation of senescent cells in the skin are considered one of the hallmarks of aging in this tissue. Mitochondria play an important role for the development of cellular senescence, in particular stress\u2010induced senescence of human cells. However, many aspects of mitochondrial physiology relevant to cellular senescence and extrinsic skin aging remain to be unraveled. Here, we demonstrate that mitochondria damaged by UVB irradiation of human dermal fibroblasts (HDF) are eliminated by NIX\u2010dependent mitophagy and that this process is important for cell survival under these conditions. Additionally, UVB\u2010irradiation of human dermal fibroblasts (HDF) induces the shedding of extracellular vesicles (EVs), and this process is significantly enhanced in UVB\u2010irradiated NIX\u2010depleted cells. Our findings establish NIX as the main mitophagy receptor in the process of UVB\u2010induced senescence and suggest the release of EVs as an alternative mechanism of mitochondrial quality control in HDF.<\/jats:p>","DOI":"10.1111\/acel.14186","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T02:54:21Z","timestamp":1716000861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Elimination of damaged mitochondria during UVB\u2010induced senescence is orchestrated by NIX\u2010dependent mitophagy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-9636","authenticated-orcid":false,"given":"Maria","family":"Cavinato","sequence":"first","affiliation":[{"name":"Institute for Biomedical Aging Research University of Innsbruck  Innsbruck Austria"},{"name":"Center for Molecular Biosciences Innsbruck (CMBI)  Innsbruck 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