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This study recruited a large prospective Caucasian cohort from the UK Biobank. Participants were assessed at baseline with handgrip strength and muscle mass and were categorized into groups of non\u2010sarcopenia, probable sarcopenia, and confirmed sarcopenia. Kaplan\u2013Meier method and Cox proportional hazards model were used to explore the association between sarcopenia and the incidence of AF. The genetic predisposition of AF was assessed by polygenic risk score. Sensitivity analyses were performed to validate the results. A total of 384,433 participants with a median age of 58\u2009years and 54.3% women were enrolled in this study. There were 24,007 cases of new\u2010onset AF over a median follow\u2010up of 12.56\u2009years. The groups of non\u2010sarcopenia, probable sarcopenia, and confirmed sarcopenia accounted for 22,290 (6.1%), 1665 (9.2%), and 52 (11.9%) cases, respectively. Compared with the non\u2010sarcopenia group, participants with probable sarcopenia or confirmed sarcopenia had an 8% (95% CI, 1.03\u20131.14) or 61% (95% CI, 1.23\u20132.12) higher risk of AF incidence. The findings remained robust in multiple sensitivity analyses, such as subgroup analysis and further adjustment of genetic predisposition. Notably, the association between sarcopenia and a high AF risk was more pronounced in younger participants, women, and those with valvular heart disease. In conclusion, sarcopenia was associated with a high long\u2010term risk of AF in Caucasians, supporting sarcopenia as a new independent risk factor of AF.<\/jats:p>","DOI":"10.1111\/acel.14198","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:15:49Z","timestamp":1715613349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Association of sarcopenia with the long\u2010term risk of atrial fibrillation: A prospective cohort study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3441-7918","authenticated-orcid":false,"given":"Yiyang","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Cardiology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology 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