{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:15:34Z","timestamp":1788909334395,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aging progresses through the interaction of metabolic processes, including changes in the immune and endocrine systems. Glucocorticoids (GCs), which are regulated by the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis, play an important role in regulating metabolism and immune responses. However, the age\u2010related changes in the secretion mechanisms of GCs remain elusive. Here, we found that corticosterone (CORT) secretion follows a circadian rhythm in young mice, whereas it oversecreted throughout the day in aged mice &gt;18\u2009months old, resulting in the disappearance of diurnal variation. Furthermore, senescent cells progressively accumulated in the zF of the adrenal gland as mice aged beyond 18\u2009months. This accumulation was accompanied by an increase in the number of Ad4BP\/SF1 (SF1), a key transcription factor, strongly expressing cells (SF1\u2010high positive: HP). Removal of senescent cells with senolytics, dasatinib, and quercetin resulted in the reduction of the number of SF1\u2010HP cells and recovery of CORT diurnal oscillation in 24\u2010month\u2010old mice. Similarly, administration of a neutralizing antibody against IL1\u03b2, which was found to be strongly expressed in the adrenocortical cells of the zF, resulted in a marked decrease in SF1\u2010HP cells and restoration of the CORT circadian rhythm. Our findings suggest that the disappearance of CORT diurnal oscillation is a characteristic of aging individuals and is caused by the secretion of IL1\u03b2, one of the SASPs, from senescent cells that accumulate in the zF of the adrenal cortex. These findings provide a novel insight into aging. Age\u2010related hypersecretory GCs could be a potential therapeutic target for aging\u2010related diseases.<\/jats:p>","DOI":"10.1111\/acel.14206","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T06:24:53Z","timestamp":1716272693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via <scp>IL1\u03b2<\/scp> secretion"],"prefix":"10.1111","volume":"23","author":[{"given":"Noriyuki","family":"Okudaira","sequence":"first","affiliation":[{"name":"Department of Biochemistry Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010Ho","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Teikyo University School of Medicine  Tokyo 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