{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:28:10Z","timestamp":1788413290885,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["400234"],"award-info":[{"award-number":["400234"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["971403"],"award-info":[{"award-number":["971403"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020978","name":"Institute of Biochemistry and Biophysics, University of Tehran","doi-asserted-by":"publisher","award":["6401007\/6\/34"],"award-info":[{"award-number":["6401007\/6\/34"]}],"id":[{"id":"10.13039\/501100020978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024506","name":"Faculty of Medical Sciences, Tarbiat Modares University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder affecting the central nervous system. Evidence suggests that age\u2010related neurodegeneration contributes to disability progression during the chronic stages of MS. Aging is characterized by decreased regeneration potential and impaired myelin repair in the brain. It is hypothesized that accelerated cellular aging contributes to the functional decline associated with neurodegenerative diseases. We assessed the impact of aging on myelin content in the corpus callosum (CC) and compared aging with the long\u2010term demyelination (LTD) consequents induced by 12\u2009weeks of feeding with a cuprizone (CPZ) diet. Initially, evaluating myelin content in 2\u2010, 6\u2010, and 18\u2010month\u2010old mice revealed a reduction in myelin content, particularly at 18\u2009months. Myelin thickness was decreased and the g\u2010ratio increased in aged mice. Although a lower myelin content and higher g\u2010ratio were observed in LTD model mice, compared to the normally aged mice, both aging and LTD exhibited relatively similar myelin ultrastructure. Our findings provide evidence that LTD exhibits the hallmarks of aging such as elevated expression of senescence\u2010associated genes, mitochondrial dysfunction, and high level of oxidative stress as observed following normal aging. We also investigated the senescence\u2010associated \u03b2\u2010galactosidase activity in O4\n                    <jats:sup>+<\/jats:sup>\n                    late oligodendrocyte progenitor cells (OPCs). The senescent O4\n                    <jats:sup>+<\/jats:sup>\n                    \/\u03b2\u2010galactosidase\n                    <jats:sup>+<\/jats:sup>\n                    cells were elevated in the CPZ diet. Our data showed that the myelin degeneration in CC occurs throughout the lifespan, and LTD induced by CPZ accelerates the aging process which may explain the impairment of myelin repair in patients with progressive MS.\n                  <\/jats:p>","DOI":"10.1111\/acel.14211","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T06:43:49Z","timestamp":1716878629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term demyelination and aging\u2010associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosis"],"prefix":"10.1111","volume":"23","author":[{"given":"Elham","family":"Parandavar","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Biophysics University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Shafizadeh","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-465X","authenticated-orcid":false,"given":"Shahin","family":"Ahmadian","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-6171","authenticated-orcid":false,"given":"Mohammad","family":"Javan","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medical Sciences Tarbiat Modares University  Tehran Iran"},{"name":"Institute for Brain and Cognition Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000818"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2399"},{"key":"e_1_2_11_4_1","article-title":"Microglial cell dysregulation in brain aging and neurodegeneration","volume":"7","author":"Bernhardi Montgomery R. V.","year":"2015","journal-title":"Frontiers in Aging Neuroscience"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1112-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64125"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.0106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.09.018"},{"issue":"3","key":"e_1_2_11_9_1","first-page":"527","article-title":"Progressive multiple sclerosis: From pathogenic mechanisms to treatment","volume":"140","author":"Correale J.","year":"2017","journal-title":"Brain"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/17590914221118502"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.191"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13819"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102722"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.12.029"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00988-z"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.10.014"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471140856.tx2011s67"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13403"},{"issue":"4","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/brb3.61","article-title":"The relationship between nerve conduction velocity and fiber morphology during peripheral nerve regeneration","volume":"2","author":"Ikeda M.","year":"2012","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120842"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09603"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21625"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45474"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136485"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.709596"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00870.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010009\u20100591\u20103"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.4.19172"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102937"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.039"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.645593"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00221-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10714"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1673-8527(08)60099-5"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010018\u20100515\u20103"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.08.015"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818348116"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13338"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01774-9"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-24152-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.11.019"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.07.074"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205216"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.11.018"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2018"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00120"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac307"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01905.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8060338"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0588-8"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2228"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0372-9"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.14211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T11:25:25Z","timestamp":1729250725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.14211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/acel.14211"],"URL":"https:\/\/doi.org\/10.1111\/acel.14211","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"assertion":[{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14211"}}