{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:56:08Z","timestamp":1792151768530,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023NSFSC1525"],"award-info":[{"award-number":["2023NSFSC1525"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sarcopenia is a significant geriatric syndrome that involves the loss of skeletal muscle mass and strength. Due to its substantial endocrine role, the metabolic microenvironment of skeletal muscle undergoes changes with age. Examining the pathogenesis of sarcopenia through focusing on metabolic dysregulation could offer insights for developing more effective intervention strategies. In this study, we analyzed the transcriptomics data to identify specific genes involved in the regulation of metabolism in skeletal muscle during the development of sarcopenia. Three machine learning algorithms were employed to screen key target genes exhibiting strong correlations with metabolism, which were further validated using RNA\u2010sequencing data and publicly accessible datasets. Among them, the metabolic enzyme nicotinamide N\u2010methyltransferase (NNMT) was elevated in sarcopenia, and predicted sarcopenia with an area under the curve exceeding 0.7, suggesting it as a potential therapeutic target for sarcopenia. As expected, inhibition of NNMT improved the grip strength in aging mice and alleviated age\u2010related decline in the mass index of the quadriceps femoris muscles and whole\u2010body lean mass index. Additionally, the NNMTi treatment increased the levels of nicotinamide adenine dinucleotide (NAD<jats:sup>+<\/jats:sup>) content, as well as PGC1\u03b1 and p\u2010AMPK expression in the muscles of both the D\u2010galactose\u2010treated mouse model and naturally aging mouse model. Overall, this work demonstrates NNMT as a promising target for preventing age\u2010related decline in muscle mass and strength.<\/jats:p>","DOI":"10.1111\/acel.14236","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T07:40:50Z","timestamp":1717573250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Identification of nicotinamide N\u2010methyltransferase as a promising therapeutic target for sarcopenia"],"prefix":"10.1111","volume":"23","author":[{"given":"Rui","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Jiujiang No 1 People's Hospital  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quhong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics, General Practice Ward\/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-779X","authenticated-orcid":false,"given":"Jirong","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116539"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010019\u201009837\u2010y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000313\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030338"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.05.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084205"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010014\u20103490\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201026882\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/life10100233"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku864"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.07.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9924314"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbac013"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010022\u201008737\u20109"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12887"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11010136"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013694\u20101"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.09.013"},{"key":"e_1_2_10_22_1","unstructured":"Nations U. 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