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BACE1 cleavage of APP is the rate\u2010limiting step for amyloid\u2010\u03b2 production and plaque formation in AD. Although the alteration of BACE1 expression in AD has been investigated, the underlying mechanisms remain unknown. In this study, we determined MEIS2 was notably elevated in AD models and AD patients. Alterations in the expression of MEIS2 can modulate the levels of BACE1. MEIS2 downregulation improved the learning and memory retention of AD mice and decreased the number of amyloid plaques. MEIS2 binds to the BACE1 promoter, positively regulates BACE1 expression, and accelerates APP amyloid degradation in\u00a0vitro. Therefore, our findings suggest that MEIS2 might be a critical transcription factor in AD, since it regulates BACE1 expression and accelerates BACE1\u2010mediated APP amyloidogenic cleavage. MEIS2 is a promising early intervention target for AD treatment.<\/jats:p>","DOI":"10.1111\/acel.14260","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T09:20:20Z","timestamp":1720776020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease"],"prefix":"10.1111","volume":"23","author":[{"given":"Yuting","family":"Cui","sequence":"first","affiliation":[{"name":"Clinical Laboratory of Xuanwu Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Xuanwu Hospital, Capital Medical University  Beijing People's Republic of 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