{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:33:36Z","timestamp":1788572016990,"version":"build-2803163510"},"reference-count":82,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal age is one of the most important factors affecting the success of maternal pregnancy. Uterine aging is the leading cause of pregnancy failure in older women. However, how uterine aging affects uterine receptivity and decidualization is unclear. In this study, naturally aged one\u2010year\u2010old female mice were used to investigate effects of maternal age on embryo implantation during early pregnancy. In our study, we found abnormal uterine receptivity in aged mice. Aged mouse uterus indicates a decrease in nuclear LAMIN A, and an increase in PRELAMIN A and PROGERIN. In aged mouse uterus, double\u2010stranded DNA (dsDNA) in cytoplasmic fraction is significantly increased. PROGERIN overexpression in mouse uterine epithelial cells and epithelial organoids leads to nuclear DNA leakage and impaired uterine receptivity. DNase I, DNase II, and TREX1 are obviously reduced in aged mouse uterus. Treatments with foreign DNA or STING agonist significantly downregulate uterine receptivity markers and activate cGAS\u2010STING pathway. Uterine estrogen (E\n                    <jats:sub>2<\/jats:sub>\n                    ) concentration is significantly increased in aged mice. After ovariectomized mice are treated with a high level of E\n                    <jats:sub>2<\/jats:sub>\n                    , there are significant increase of PROGERIN and cytoplasmic DNA, and activation of cGAS\u2010STING pathway. CD14 is significantly increased in aged uterus. Intrauterine CD14 injection inhibits embryo implantation. In\u00a0vitro CD14 treatment of cultured epithelial cells or epithelial organoids decreases uterine receptivity. Uterine abnormality in aged mouse can be partially rescued by STING inhibitor. In conclusion, uterine PROGERIN increase in aged mouse uterus results in cytoplasmic DNA accumulation and cGAS\u2010STING pathway activation. CD14 secretion in aged uterus impairs uterine receptivity.\n                  <\/jats:p>","DOI":"10.1111\/acel.14303","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T01:40:58Z","timestamp":1723081258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The activation of cGAS\u2010STING pathway causes abnormal uterine receptivity in aged mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Si\u2010Ting","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Plateau Mountain Animal Genetics, Breeding and Reproduction, Ministry of Education Guizhou University  Guiyang China"},{"name":"College of Animal Science Guizhou University  Guiyang China"},{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 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