{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:15:55Z","timestamp":1790680555024,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670939"],"award-info":[{"award-number":["81670939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age\u2010related hearing loss (AHL) is the most common sensory disorder amongst the older population. Inflammaging is a \u2248chronic low\u2010grade inflammation that worsens with age and is an early sign of AHL; however, the underlying mechanisms remain unclear. We used electrophysiological and genetic approaches to establish the importance of interleukin 6 (IL\u20106)\u2010dependent inflammation in AHL. Elevated IL\u20106 in the cochlea enhanced Ca<jats:sub>v<\/jats:sub>1.3 calcium channel function in the inner hair cell (IHC) synapse in mice with AHL. IL\u20106 upregulated the Ca<jats:sub>v<\/jats:sub>1.3 channel via the Janus kinase\u2010mitogen activated kinase pathway, causing neurotransmitter excitotoxicity and synapse impairment; IL\u20106 deficiency or the administration of a Ca<jats:sub>v<\/jats:sub>1.3 channel blocker attenuated this age\u2010related damage, and rescued hearing loss. Thus, IL\u20106\u2010dependent inflammaging upregulated the Ca<jats:sub>v<\/jats:sub>1.3 channel in IHCs, contributing to AHL. Our findings could help the comprehensive understanding of inflammaging's effects on AHL, aiding in early intervention to protect against hearing decline.<\/jats:p>","DOI":"10.1111\/acel.14305","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T03:45:46Z","timestamp":1723779946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Upregulation of the Ca<sub>v<\/sub>1.3 channel in inner hair cells by interleukin 6\u2010dependent inflammaging contributes to age\u2010related hearing loss"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5393-4863","authenticated-orcid":false,"given":"Mingshun","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of New Drug Pharmacology and Toxicology, The Hebei Collaboration Innovation 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