{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:21:59Z","timestamp":1791476519563,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302096"],"award-info":[{"award-number":["32302096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aging\u2010related metabolic disorders seriously affect the lifespan of middle\u2010aged and older people, potentially due to disruptions in the adaptive immune and gut microbial profiles. Dietary intervention offers a promising strategy for maintaining metabolic health. This study aimed to investigate the ameliorative effect of 2\u2032\u2010fucosyllactose (2'\u2010FL) on aging\u2010induced metabolic dysfunction and the underlying mechanisms. The results revealed that 2'\u2010FL significantly relieved aging\u2010related metabolic disorders, including weight gain, lipid deposition, dyslipidemia, glucose intolerance, systemic inflammation, and abnormal hepatic metabolism. Flow cytometry analysis revealed a significant reduction in T cytotoxic (Tc), T helper (Th), and regulatory T (Treg) cells and a significant increase in Th17 cells in aged mice, while 2'\u2010FL relieved the aging\u2010induced proportional changes in Th and Th17 subtypes. The aging intestinal microecology was characterized by higher Th17\/Treg ratios, impaired gut barrier function, lower gut bacterial diversity, decreased abundance of beneficial genera including\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Colidextribacter<\/jats:italic>\n                    ,\n                    <jats:italic>Mucispirillum<\/jats:italic>\n                    , and\n                    <jats:italic>Lachnoclostridium<\/jats:italic>\n                    , and increased abundance of harmful bacteria including\n                    <jats:italic>Turicibacter<\/jats:italic>\n                    and\n                    <jats:italic>Desulfovibrio<\/jats:italic>\n                    , which was ameliorated by 2'\u2010FL treatment. These findings highlight that 2'\u2010FL is an ideal dietary prebiotic for improving aging\u2010related metabolic disorders by modulating both the adaptive immune system and the gut microbial profile.\n                  <\/jats:p>","DOI":"10.1111\/acel.14343","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T06:39:59Z","timestamp":1726814399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["2'\u2010Fucosyllactose attenuates aging\u2010related metabolic disorders through modulating gut microbiome\u2010T cell axis"],"prefix":"10.1111","volume":"24","author":[{"given":"Ang","family":"Li","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Kou","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruishan","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-7515","authenticated-orcid":false,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11\u20101274"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000557\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202100096"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c04410"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2199072"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00114"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47866"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20101511"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15725"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax0860"},{"issue":"106","key":"e_1_2_10_13_1","first-page":"1","article-title":"Prevalence of obesity among older adults in the United States, 2007\u20132010","author":"Fakhouri T. 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