{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:00:10Z","timestamp":1792094410437,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) has been suggested to increase the risk of memory decline and Alzheimer's disease (AD), the main cause of dementia in the elderly. However, direct evidence about whether COVID\u201019 induces AD\u2010like neuropathological changes in the brain, especially post recovery from acute infection, is still lacking. Here, using postmortem human brain samples, we found abnormal accumulation of hyperphosphorylated tau protein in the hippocampus and medial entorhinal cortex within 4\u201313\u2009months post clinically recovery from acute COVID\u201019, together with prolonged activation of glia cells and increases in inflammatory factors, even though no SARS\u2010COV\u20102 invasion was detected in these regions. By contrast, COVID\u201019 did not change beta\u2010amyloid deposition and hippocampal neuron number, and had limited effects on AD\u2010related pathological phenotypes in olfactory circuits including olfactory bulb, anterior olfactory nucleus, olfactory tubercle, piriform cortex and lateral entorhinal cortex. These results provide neuropathological evidences linking COVID\u201019 with prognostic increase of risk for AD.<\/jats:p>","DOI":"10.1111\/acel.14352","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:25:39Z","timestamp":1727673939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Emerging signs of Alzheimer\u2010like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID\u201019"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-7268","authenticated-orcid":false,"given":"Xuetao","family":"Qi","sequence":"first","affiliation":[{"name":"Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences Peking University  Beijing China"},{"name":"Key Laboratory for Neuroscience, Ministry of Education\/National Health Commission Peking University  Beijing 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