{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:15:42Z","timestamp":1779880542554,"version":"3.53.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Morphological mouse phenotyping plays a pivotal role in the translational setting and even more in the area of auditory research, where mouse is a central model organism due to the evolutionary genetic relationship and morpho\u2010functional analogies with the human auditory system. However, some results obtained in murine models cannot be translated to humans due to the inadequate description of experimental conditions underlying poor reproducibility. We approach the characterization of the aging process of the mouse cochlea in animals up to 18\u2009months of age belonging to two of the most used outbred (CD1) and inbred (C57BL\/6N) strains. Striving to reduce any environmental variable we performed our study compliantly to the ARRIVE guidelines. We integrated instrumental data (auditory brainstem response test), with morphological analyses to correlate functional discrepancies to morphological changes and track the differences in the evolution of sensorineural hearing loss in the two strains. We featured the localization of Gipc3, Myosin VIIa, and TMC1 in hair cells of the Corti organ as well as NF 200 and the density of type I neuron in the spiral ganglion. We outlined age\u2010related hearing loss (ARHL) in both strains, and a clear drop in the selected marker localization. However, in CD1 we detected a different trend allowing the identification of potential strain\u2010specific mechanisms, namely an increase in myosin VIIa in 6\u2009months aging mice in comparison to 2\u2009months old animals. Our findings represent an asset to investigate the strain\u2010dependent physiological trigger of ARHL providing new insights in the translational area.<\/jats:p>","DOI":"10.1111\/acel.14362","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T06:49:28Z","timestamp":1730443768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Morphological phenotyping of the aging cochlea in inbred C57BL\/6N and outbred CD1 mouse strains"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-4087","authenticated-orcid":false,"given":"Chiara","family":"Attanasio","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Animal Production University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Palladino","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Giaquinto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Production University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Scavizzi","sequence":"additional","affiliation":[{"name":"National Research Council, CNR\u2014Institute of Cellular Biology and Neurobiology  Monterotondo Italy"},{"name":"National Research Council, CNR\u2014Institute of Biochemistry and Cell Biology \u2010 International Campus EMMA\u2010INFRAFRONTIER\u2010IMPC  Monterotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Raspa","sequence":"additional","affiliation":[{"name":"National Research Council, CNR\u2014Institute of Cellular Biology and Neurobiology  Monterotondo Italy"},{"name":"National Research Council, CNR\u2014Institute of Biochemistry and Cell Biology \u2010 International Campus EMMA\u2010INFRAFRONTIER\u2010IMPC  Monterotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Peres","sequence":"additional","affiliation":[{"name":"National Research Council, CNR\u2014Institute of Cellular Biology and Neurobiology  Monterotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Anastasio","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Scocco","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lucini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Production University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"de Girolamo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Production University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Production University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"De Felice","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/174596a0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368399"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23815"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2024.108989"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1200"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033506"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.11.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12340"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3791\/60299"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.803973"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00206098009070071"},{"key":"e_1_2_12_13_1","unstructured":"IMPC|International Mouse Phenotyping Consortium. 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