{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:20:07Z","timestamp":1791980407222,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["No. ZR202210210042"],"award-info":[{"award-number":["No. ZR202210210042"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer's diseases (AD) patients suffer from more serious bone loss than cognitively normal subjects at the same age. Type H blood vessels were tightly associated with bone homeostasis. However, few studies have concentrated on bone vascular alteration and its role in AD\u2010related bone loss. In this study, APP\/PS1 mice (4\u2010 and 8\u2010month\u2010old) and age\u2010matched wild\u2010type mice were used to assess the bone vascular alteration and its role in AD\u2010related bone loss. Transmission electron microscopy, immunofluorescence staining and iGPS 1.0 software database were utilized to investigate the molecular mechanism. Mitochondrial division inhibitor (Mdivi\u20101) and GSK\u20103\u03b2 inhibitor (LiCl) were used to rescue type H blood vessels injury and verify the molecular mechanism. Our results revealed that APP\/PS1 mice exhibited more serious bone blood vessels injury and bone loss during ageing. The bone blood vessel injury, especially in type H blood vessels, was accompanied by impaired vascularized osteogenesis in APP\/PS1 mice. Further exploration indicated that beta\u2010amyloid (A\u03b2) promoted the apoptosis of vascular endothelial cells (ECs) and resulted in type H blood vessels injury. Mechanistically, A\u03b2\u2010induced excessive mitochondrial fission was found to be essential for the apoptosis of ECs. GSK\u20103\u03b2 was identified as a key regulatory target of A\u03b2\u2010induced excessive mitochondrial fission and bone loss. The findings delineated that A\u03b2\u2010induced excessive mitochondrial fission drives type H blood vessels injury, leading to aggravate bone loss in APP\/PS1 mice and GSK\u20103\u03b2 inhibitor emerges as a potential therapeutic strategy.<\/jats:p>","DOI":"10.1111\/acel.14374","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T09:41:01Z","timestamp":1729071661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A\u03b2 \u2010induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP\/PS1 mice with Alzheimer's diseases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-679X","authenticated-orcid":false,"given":"Weidong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Bone Metabolism School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"},{"name":"Center of Osteoporosis and Bone Mineral Research Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"},{"name":"Center of Osteoporosis and Bone Mineral Research Shandong University  Jinan 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Provincial Clinical Research Center for Oral Diseases  Jinan China"},{"name":"Center of Osteoporosis and Bone Mineral Research Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoka","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"},{"name":"Center of Osteoporosis and Bone Mineral Research Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-1382","authenticated-orcid":false,"given":"Minqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"},{"name":"Center of Osteoporosis and Bone Mineral Research Shandong University  Jinan China"},{"name":"School of Clinical Medicine, Jining Medical University  Jining 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