{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:52Z","timestamp":1787013772262,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01\u2010AG\u20106\u20102101"],"award-info":[{"award-number":["N01\u2010AG\u20106\u20102101"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01\u2010AG\u20106\u20102103"],"award-info":[{"award-number":["N01\u2010AG\u20106\u20102103"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["N01\u2010AG\u20106\u20102106"],"award-info":[{"award-number":["N01\u2010AG\u20106\u20102106"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01\u2010AG\u2010059729"],"award-info":[{"award-number":["R01\u2010AG\u2010059729"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01\u2010AG028050"],"award-info":[{"award-number":["R01\u2010AG028050"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01\u2010NR012459"],"award-info":[{"award-number":["R01\u2010NR012459"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aims to understand the metabolic mechanisms of unintentional weight loss in older adults. We investigated plasma metabolite associations of subsequent weight change over 2\u2009years in 1536 previously weight stable participants (mean age 74.6\u2009years, 50% women, 35% Black) from the Health, Aging and Body Composition (Health\n                    <jats:styled-content style=\"fixed-case\">ABC<\/jats:styled-content>\n                    ) Study. Multinomial logistic regressions were used to examine associations of the 442 metabolites with weight loss with\/without an intention and weight gain &gt;3% annually relative to weight stability. The metabolite associations of unintentional weight loss differed from those of intentional weight loss and weight gain. Lower levels of aromatic amino acids, phospholipids, long\u2010chain poly\u2010unsaturated triglycerides, and higher levels of amino acid derivatives, poly\u2010unsaturated fatty acids, and carbohydrates were associated with higher odds of unintentional weight loss after adjusting for age, sex, race, and\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    categories. Prevalent diseases attenuated four and lower mid\u2010thigh muscle mass and poorer appetite each attenuated 2 of 77 identified metabolite associations by &gt;20%, respectively. Other factors (e.g., energy expenditure, diet, and medication) attenuated all associations by &lt;20%. While 16 metabolite associations were attenuated by 20%\u201348% when adjusting for all these risk factors, 47 metabolite associations remained significant. Altered amino acid metabolism, impaired mitochondrial fatty acid oxidation, and inflammaging implicated by identified metabolites appear to precede unintentional weight loss in Health ABC older adults. Furthermore, these pathways seem to be associated with prevalent diseases especially diabetes, lower muscle mass, and poorer appetite.\n                  <\/jats:p>","DOI":"10.1111\/acel.14410","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T03:51:46Z","timestamp":1731642706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolomic characterization of unintentional weight loss among community\u2010dwelling older Black and White men and women"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-1242","authenticated-orcid":false,"given":"Shanshan","family":"Yao","sequence":"first","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Marron","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh 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